IL-17F Activators
Interleukin-17F (IL-17F) is a member of the IL-17 family, a group of cytokines that play a crucial role in inflammatory responses and host defense. IL-17F is predominantly produced by Th17 cells, a subset of pro-inflammatory T helper cells. Structurally similar to IL-17A, IL-17F functions primarily as a homodimer, but it can also form heterodimers with IL-17A. These cytokines exert their effects by binding to the IL-17 receptor, which triggers a signaling cascade leading to the induction of other pro-inflammatory cytokines, chemokines, and metalloproteases.
IL-17F is involved in the pathogenesis of various inflammatory and autoimmune conditions, such as asthma, rheumatoid arthritis, and psoriasis, by recruiting neutrophils and macrophages to the site of inflammation and enhancing the barrier function of epithelial cells. It also plays a role in defending against extracellular pathogens, particularly at mucosal surfaces.The expression of IL-17F is induced by a combination of cytokines that promote Th17 cell differentiation, including IL-1β, IL-6, IL-23, and transforming growth factor-beta (TGF-β). Its activity is modulated by the local cytokine environment and is subject to regulation by various transcription factors, such as RORγt, which is considered the master regulator of Th17 cell differentiation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the activation of signaling pathways that induce IL-17F expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin raises intracellular calcium levels, which can synergize with PMA to activate T cells and promote IL-17F expression. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS activates toll-like receptor 4 (TLR4) on immune cells, potentially enhancing the differentiation of Th17 cells and IL-17F production. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 can modulate immune responses and has been shown to enhance Th17 cell differentiation, potentially increasing IL-17F expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels, which may influence T cell activation and cytokine production, including IL-17F. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 modulates immune responses and has been reported to influence Th17 cell differentiation and cytokine expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory properties and can modulate cytokine production, potentially affecting IL-17F levels. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, an HDAC inhibitor, can affect gene expression and has been shown to influence cytokine production in immune cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a vitamin A derivative, modulates immune responses and has been shown to affect Th17 cell differentiation. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
The active form of vitamin D3, it can modulate immune function and potentially influence IL-17F expression. | ||||||