IL-12B p70 Inhibitors
IL-12B p70 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the IL-12B p70 protein, which is the active heterodimeric form of interleukin-12 (IL-12). IL-12 is composed of two subunits, IL-12A (p35) and IL-12B (p40), that together form the biologically active IL-12 p70 complex. This cytokine plays a crucial role in regulating immune responses, particularly in promoting the differentiation and activation of T cells and natural killer (NK) cells. IL-12 p70 signals through the IL-12 receptor, initiating downstream pathways that lead to the production of interferon-gamma (IFN-γ) and other immune-modulating molecules. By inhibiting IL-12B p70, these compounds prevent the assembly and function of the IL-12 heterodimer, thereby blocking its ability to engage with its receptor and trigger immune signaling cascades.
In research, IL-12B p70 inhibitors are valuable tools for investigating the specific role of IL-12 in immune regulation. By blocking the activity of IL-12B p70, researchers can explore how the disruption of IL-12 signaling affects immune cell function, particularly the activation and differentiation of T cells and NK cells. These inhibitors help scientists understand how IL-12B p70 contributes to cytokine production, immune cell recruitment, and the amplification of immune responses. Additionally, IL-12B p70 inhibitors allow for the study of how IL-12 interacts with other cytokines and immune regulators, providing insights into its role in maintaining immune balance. Through the use of IL-12B p70 inhibitors, researchers can also explore the broader implications of IL-12 signaling in various immune processes, offering a clearer understanding of how this cytokine shapes immune system function and cellular communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone might decrease IL-12B p70 expression by suppressing the activity of transcription factor NF-κB, which is integral to the cytokine's gene transcription process. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin could downregulate IL-12B p70 synthesis by hindering the phosphorylation and activation of STAT proteins in the JAK-STAT signaling pathway, which is critical for the expression of IL-12B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is likely to reduce IL-12B p70 levels by obstructing the translocation of the p65 subunit of NF-κB to the nucleus, thus decreasing the transcription of the IL-12B gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may downregulate the synthesis of IL-12B p70 by blocking the NF-κB pathway, specifically by preventing the degradation of IκB, an inhibitor of NF-κB. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane might decrease IL-12B p70 expression by both inhibiting the NF-κB pathway and activating the antioxidant response element via Nrf2, which can lead to a reduction in inflammatory cytokine production. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is thought to inhibit the synthesis of IL-12B p70 by blocking the phosphorylation of STAT proteins in the JAK-STAT pathway and preventing the activation of NF-κB. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could reduce IL-12B p70 expression by hindering the DNA binding activity of NF-κB, as well as influencing the differentiation of T-cells that are responsive to IL-12B p70 signaling. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin may inhibit the production of IL-12B p70 by preventing the nuclear translocation of NF-κB and the subsequent transcriptional activation of its target genes, including IL-12B. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein could downregulate IL-12B p70 expression by inhibiting the kinase activity responsible for the activation of STAT proteins in the JAK-STAT pathway and by blocking the DNA-binding activity of NF-κB. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
Andrographolide has the potential to reduce IL-12B p70 levels by directly inhibiting the DNA-binding activity of NF-κB, thus decreasing the transcription of the IL-12B gene. | ||||||