IL-12B p40 Inhibitors
IL-12B p40 inhibitors belong to a specific class of chemical compounds designed to target and modulate the activity of the interleukin-12 subunit p40. Interleukin-12 (IL-12) is a cytokine, a small protein molecule that plays a critical role in the immune system's regulation and response to infections and inflammatory processes. IL-12 consists of two subunits, p35 and p40, which combine to form the biologically active IL-12 molecule. The p40 subunit is shared with another cytokine called IL-23, which also plays a crucial role in immune responses.
IL-12B p40 inhibitors are designed to specifically interfere with the activity of the p40 subunit, preventing its interaction with other molecules in the immune system that initiate pro-inflammatory responses. By inhibiting p40, these compounds can modulate the immune system's functioning, dampening excessive inflammation that can contribute to autoimmune diseases and chronic inflammatory conditions. Researchers have been investigating IL-12B p40 inhibitors to further understand autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn's disease, as these conditions often involve an overactive immune response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This synthetic corticosteroid has broad anti-inflammatory effects and can suppress the immune system, potentially reducing the expression of various cytokines, including IL-12B p40. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Found in turmeric, curcumin has anti-inflammatory and antioxidant properties. It has been shown to inhibit NF-κB, potentially leading to decreased IL-12B p40 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This natural compound found in red wine has anti-inflammatory and antioxidant effects. It might inhibit various signaling pathways involved in cytokine expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane has anti-inflammatory properties and has been shown to inhibit NF-κB, which could potentially reduce IL-12B p40 levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
This flavonoid has anti-inflammatory and antioxidant properties. It has been shown to inhibit NF-κB and could potentially reduce IL-12B p40 expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
This compound is a known NF-κB inhibitor, and its use could potentially lead to reduced IL-12B p40 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, EGCG has anti-inflammatory and antioxidant properties. It might inhibit various signaling pathways and reduce IL-12B p40 levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a compound that can reduce the expression of various cytokines, potentially including IL-12B p40. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin might have effects on cytokine expression, potentially including IL-12B p40. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
This antioxidant might reduce oxidative stress and have effects on cytokine expression, including IL-12B p40. | ||||||