IgG3 Inhibitors
IgG3 inhibitors are a class of compounds that specifically target the expression or function of the IgG3 subclass of immunoglobulins. Immunoglobulins, often referred to as antibodies, are key proteins of the immune system that recognize and bind to specific antigens, such as pathogens or foreign substances. The IgG class is the most abundant type of antibody present in the bloodstream, and it's further subdivided into four subclasses: IgG1, IgG2, IgG3, and IgG4. Among these, IgG3 stands out due to its high affinity for antigens and its potent ability to activate the complement system, a group of proteins that assist antibodies in clearing pathogens. Therefore, any compound that can inhibit IgG3 can potentially modulate these immune functions.
The precise mechanisms by which IgG3 inhibitors operate can vary widely. Some might prevent the transcription or translation of the genes responsible for IgG3 production, while others might block the pathways that lead to the post-translational modifications essential for IgG3's activity. Furthermore, some inhibitors might target the stability of IgG3, leading to its rapid degradation, or they might hinder the binding of IgG3 to its specific antigens, thus negating its function. The development and study of IgG3 inhibitors are rooted in a deep understanding of molecular biology, biochemistry, and immunology. While their specific applications can be diverse, the core principle behind IgG3 inhibitors remains the modulation of the IgG3 antibody, either at the expression or functional level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid known to inhibit inflammation by suppressing the transcription of various cytokines. This could downregulate the overall immune response, potentially reducing the expression of antibodies like IgG3. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $36.00 $107.00 | 1 | |
Mycophenolate mofetil inhibits the enzyme inosine monophosphate dehydrogenase, leading to a decreased synthesis of guanosine nucleotides. This affects lymphocyte proliferation, potentially suppressing antibody production. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor which can suppress both T-cell and B-cell activation. Since B-cells produce antibodies, inhibiting their activation could lead to reduced IgG3 expression. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Azathioprine inhibits purine synthesis, impairing DNA replication in lymphocytes. This can limit lymphocyte proliferation, which may decrease antibody production including IgG3. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine can impair the processing and presentation of antigens, which may lead to a reduced immune response. This might have a downstream effect on the production of antibodies like IgG3. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $81.00 | 5 | |
Leflunomide inhibits dihydroorotate dehydrogenase, leading to reduced pyrimidine synthesis. This might impair lymphocyte proliferation, potentially decreasing IgG3 expression. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Tacrolimus binds to FK-binding protein, inhibiting calcineurin and thus T-cell activation. This could indirectly reduce B-cell activation and IgG3 production. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, reducing purine and pyrimidine synthesis. This could impair DNA replication in lymphocytes and might reduce IgG3 expression. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $71.00 $102.00 | ||
6-Mercaptopurine is a purine analogue that can be incorporated into DNA, potentially inhibiting lymphocyte proliferation. This might lead to decreased IgG3 expression. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $60.00 $75.00 $125.00 $205.00 | 8 | |
Sulfasalazine can inhibit the NF-kB signaling pathway which plays a role in immune cell activation. Reduced activation may lead to lower IgG3 production. | ||||||