IgG2 Inhibitors
IgG2 inhibitors belong to a distinct chemical class primarily recognized for their capacity to modulate the immune response by selectively targeting and inhibiting the activity of immunoglobulin G subtype 2 (IgG2). Immunoglobulins, commonly known as antibodies, play a crucial role in the immune system's defense mechanisms, and IgG2 is one of the four subclasses of IgG. These inhibitors exhibit a high degree of specificity towards IgG2, selectively interfering with its biological functions. The development of IgG2 inhibitors has stemmed from a deeper understanding of the immune system and the recognition that modulating specific antibody subclasses can have profound effects on immune responses.
IgG2 inhibitors typically involve intricate designs that allow them to interact with specific binding sites on the IgG2 molecule, disrupting its normal functioning. This targeted inhibition serves as a potential avenue for influencing immune responses without broadly suppressing the entire immune system. Researchers have focused on elucidating the molecular mechanisms through which IgG2 inhibitors exert their effects, aiming to optimize their specificity and efficacy.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclophosphamide | 50-18-0 | sc-361165 sc-361165A sc-361165B sc-361165C | 50 mg 100 mg 500 mg 1 g | $76.00 $143.00 $469.00 $775.00 | 18 | |
Alkylating agent that can suppress the immune system by reducing B cell activity and proliferation, indirectly reducing IgG2 levels. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Folate pathway antagonist that can inhibit B-cell proliferation, potentially decreasing IgG2 production. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Purine synthesis inhibitor that can lead to lowered B-cell proliferation, affecting IgG2 levels indirectly. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $36.00 $107.00 | 1 | |
Inhibits inosine monophosphate dehydrogenase, which is crucial for B-cell proliferation, thus could reduce IgG2 production. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Calcineurin inhibitor that can suppress T-cell help for B cells, possibly leading to reduced IgG2 synthesis. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Inhibits T-lymphocyte activation and can indirectly diminish B cell help, potentially decreasing IgG2 levels. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Initially used as an antimalarial, it can affect immune function and might alter IgG2 levels. | ||||||
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $41.00 $133.00 $663.00 | 2 | |
Can modulate immune responses and decrease immunoglobulin production, including IgG2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that can lead to reduced B cell proliferation and consequently IgG2 levels. | ||||||
Chlorambucil | 305-03-3 | sc-204682 sc-204682A | 250 mg 1 g | $51.00 $120.00 | 3 | |
Alkylating agent that can suppress the immune system and indirectly affect IgG2 production. | ||||||