IFT52 Activators
IFT52 activators encompass a variety of chemical compounds that facilitate the functional activity of IFT52 through distinct signaling pathways and cellular mechanisms. Forskolin and IBMX elevate intracellular cAMP, which activates PKA, potentially leading to the phosphorylation of proteins that are critical for the IFT machinery where IFT52 plays a pivotal role. PMA indirectly promotes IFT52 function by activating PKC, which influences cytoskeletal organization and could enhance the assembly of IFT particles, a process crucial for IFT52's activity. Sphingosine-1-phosphate, through receptor-mediated signaling, orchestrates cytoskeletal rearrangements that may facilitate IFT52's cargo transport function. Retinoic acid and Lithium chloride modulate differentiation and Wnt signaling pathways, respectively, with downstream effects that may increase the demand for IFT52's role in ciliogenesis. Epigallocatechin gallate's inhibition of kinases could result in changes to cellular transport processes, indirectly favoring IFT52's function.
Additionally, Rolipram and FTY720 enhance cAMP and modulate sphingosine phosphate receptors, respectively, both of which can contribute to the phosphorylationof proteins associated with IFT52, thus enhancing its function in intraflagellar transport. Nicotinamide mononucleotide (NMN), by contributing to NAD+ biosynthesis and sirtuin activation, has the potential to influence cellular processes including ciliogenesis, thereby indirectly supporting IFT52 activity. All-trans retinol, beyond its role in the visual cycle, may impact cell differentiation and demand on ciliary transport, indirectly affecting IFT52. Lastly, Chlorpromazine, by altering cellular signaling and cytoskeletal dynamics, could potentially lead to an enhancement of IFT52's role in cilia assembly and maintenance. These IFT52 activators, through their targeted effects on cellular signaling and cytoskeletal organization, facilitate the enhancement of IFT52-mediated functions, integral to the intraflagellar transport that is essential for cilia and flagella assembly and maintenance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can enhance the functional activity of IFT52 by PKA-mediated phosphorylation of proteins involved in the intraflagellar transport (IFT) machinery. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX acts as a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP levels and activation of PKA. This elevated PKA activity can phosphorylate components in the IFT process, potentially enhancing IFT52 function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can influence cytoskeletal organization. PKC activation can indirectly enhance IFT52 function by promoting the assembly of IFT particles. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate binds to its receptors, initiating signaling cascades that can lead to cytoskeletal rearrangements. This can indirectly facilitate the IFT52 role in transporting cargo along the microtubules. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates signaling pathways that are involved in the differentiation of cells with cilia. IFT52, being a component of the IFT machinery, could have its activity enhanced as the formation of cilia is upregulated. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, which can lead to the stabilization of proteins involved in the Wnt signaling pathway. Enhanced Wnt signaling may indirectly augment IFT52 function necessary for ciliogenesis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol inhibits a range of kinases, altering signaling pathways which can lead to changes in cellular transport processes, indirectly enhancing IFT52's role in IFT. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor, increasing cAMP levels in cells. This can potentiate PKA activity and indirectly enhance the function of IFT52 by phosphorylation of associated proteins. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720 acts upon sphingosine phosphate receptors, modulating signaling pathways that affect the cytoskeleton and potentially enhancing the IFT52-dependent transport along axonemal microtubules. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor in the NAD+ biosynthesis pathway, which is involved in sirtuin activation. Sirtuins can influence cellular processes including those related to cilia function, thereby potentially enhancing IFT52 activity. | ||||||