IFT20 Activators
IFT20 activators are a group of chemicals capable of indirectly modulating the activity of the IFT20 protein by influencing relevant cellular processes or associated pathways. One such chemical, Retinoic Acid, can modulate ciliogenesis, affecting cilia formation and maintenance, which implicates IFT20. Similarly, Lithium Chloride can influence IFT20 through its modulation of the Wnt signaling pathways, which are integral to cilia regulation. Forskolin can play a role in affecting IFT20 activity by elevating cAMP levels, having an impact on cilia length and function. The influence of these chemicals on IFT20 stems primarily from their ability to modulate associated cellular processes and signaling pathways, with their effects being crucial in situations where the manipulation of IFT20 activity is desired.
Further, chemicals like MG-132, which inhibit the proteasome, affect protein turnover and can influence IFT20 levels or stability. IBMX, a phosphodiesterase inhibitor, elevates cAMP levels and may impact cilia and, subsequently, IFT20. Rapamycin, by inhibiting mTOR, can modulate autophagy and other cellular processes, indirectly affecting IFT20.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Can modulate ciliogenesis, possibly impacting IFT20 activity by affecting cilia formation and maintenance. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
May influence IFT20 through Wnt signaling pathways which are known to be involved in cilia regulation. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
By inhibiting FGFR signaling, it may modulate pathways involved in cilia maintenance, potentially impacting IFT20 activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
By inhibiting the proteasome, it might affect protein turnover influencing IFT20 levels or stability. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
This phosphodiesterase inhibitor can elevate cAMP levels, potentially impacting cilia and by extension, IFT20. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
It may have an impact on IFT20 through cyclin-dependent kinase inhibition affecting cell cycle and ciliogenesis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
As a PKC activator, it may affect numerous cellular processes including those related to cilia, potentially impacting IFT20. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR, it might modulate autophagy and other cellular processes, indirectly affecting IFT20. | ||||||