IF3 Activators
The protein IF3, or Initiation Factor 3, is a bacterial protein that plays an essential role in the initiation of protein synthesis. In the context of bacterial translation, initiation is a highly regulated process that involves the assembly of the small 30S ribosomal subunit with the messenger RNA (mRNA) and the initiator transfer RNA (tRNA) charged with N-formylmethionine (fMet-tRNA^fMet), which is the first amino acid incorporated into nascent proteins in prokaryotes.
IF3 binds to the small 30S ribosomal subunit and has multiple critical functions. It helps to maintain the 30S subunit in a conformation that is conducive to interacting with mRNA and initiator tRNA. One of IF3's primary roles is to prevent the premature binding of the large 50S ribosomal subunit before the mRNA and initiator tRNA are properly positioned. This ensures that the assembly of the functional 70S initiation complex, comprising the 30S and 50S subunits along with the mRNA and fMet-tRNA^fMet, occurs accurately and efficiently.
Additionally, IF3 plays a role in ensuring the fidelity of translation initiation. It helps in the selection of the correct start codon on the mRNA, usually AUG, and in the discrimination against non-initiator tRNAs, thus preventing the misincorporation of amino acids at the N-terminus of the protein being synthesized. IF3 also facilitates the release of deacylated tRNA from the E site (exit site) of the ribosome, resetting it for the next round of translation initiation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gentamicin sulfate | 1405-41-0 | sc-203334 sc-203334A sc-203334F sc-203334B sc-203334C sc-203334D sc-203334E | 1 g 5 g 50 g 100 g 1 kg 2.5 kg 7.5 kg | $56.00 $179.00 $509.00 $725.00 $1836.00 $2652.00 $6248.00 | 3 | |
Aminoglycosides interfere with bacterial protein synthesis and might indirectly affect IF3 function by altering ribosome dynamics. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline inhibits protein synthesis in bacteria and could influence processes involving IF3. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
This antibiotic inhibits bacterial protein synthesis and might have an indirect impact on IF3 activity. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Puromycin causes premature chain termination during protein synthesis and might affect the function of translation initiation factors. | ||||||
Fusidic acid | 6990-06-3 | sc-215065 | 1 g | $292.00 | ||
Fusidic Acid inhibits elongation factor G in bacteria, potentially impacting the overall process of translation including initiation. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Macrolides inhibit bacterial protein synthesis and may indirectly affect IF3-related processes. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
Neomycin disrupts protein synthesis in bacteria and could have an indirect impact on IF3. | ||||||
Kanamycin | 8063-07-8 | sc-492406 | 1 g | $500.00 | 3 | |
Kanamycin, an aminoglycoside antibiotic, might affect translation initiation processes involving IF3. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $37.00 $109.00 | 1 | |
Quinupristin works synergistically with Dalfopristin to inhibit bacterial protein synthesis and might influence IF3 activity. | ||||||