ICF45 Inhibitors
ICF45 inhibitors reference a class of chemical agents that specifically target and impede the activity of a protein, which for the context of this description we will refer to as ICF45. Assuming ICF45 plays a role in a critical biological pathway, the inhibitors of this protein could affect the function of ICF45 by binding to its active site or another relevant domain, thus preventing its normal interaction with other molecules or substrates within the cell. This inhibition could result in the modulation of the protein's function, impacting the cellular pathway in which ICF45 is involved. The discovery and design of ICF45 inhibitors would require an in-depth understanding of the protein's structure, conformational dynamics, and its role in cellular signaling or regulatory networks.
These compounds would then be characterized in various biochemical and biophysical assays to determine their binding affinity, kinetic properties, and mechanism of inhibition. The overall goal in the development of ICF45 inhibitors would be to precisely modulate the function of ICF45, aiming to achieve specific interaction with the protein and an understanding of how these interactions influence the protein's activity within its respective pathway. The intricate balance in designing these molecules hinges on their ability to effectively bind ICF45 without adversely affecting the functionality of other proteins and maintaining stability within the complex environment of the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
It inhibits inosine monophosphate dehydrogenase, leading to a reduction in guanosine triphosphate (GTP) synthesis. Reduced GTP availability can impair the guanylylation process facilitated by THG1L. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
As a guanosine analogue, ribavirin could compete with the natural guanosine substrates, potentially inhibiting the guanylylation reactions of THG1L. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
This compound is integrated into RNA during synthesis. Its incorporation may result in aberrant tRNAs, rendering them unsuitable for efficient guanylylation by THG1L. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
By intercalating into DNA and inhibiting transcription, Actinomycin D can reduce the synthesis of new tRNAs, indirectly limiting the substrate pool for THG1L. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Resembling aminoacyl-tRNAs, puromycin can be mistakenly integrated into nascent protein chains, leading to their termination. This disruption of translation can indirectly affect the turnover and demand for guanylylated tRNAs. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
This purine analogue, when incorporated into RNA, could affect the structure and function of tRNAs, making them less recognizable or suitable for guanylylation by THG1L. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine could disrupt the base-pairing in tRNA, possibly leading to misrecognition or inefficient processing by THG1L. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Excess zinc can have inhibitory effects on several RNA processing enzymes. If THG1L has zinc-sensitive motifs, its activity might be reduced in high zinc conditions. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $81.00 | 5 | |
By affecting pyrimidine synthesis, leflunomide can indirectly influence the synthesis and structure of tRNAs, possibly making them less suitable for THG1L-mediated guanylylation. | ||||||
A77 1726 | 163451-81-8 | sc-207235 | 10 mg | $78.00 | 14 | |
Like its parent compound, leflunomide, teriflunomide can affect tRNA synthesis and structure by limiting pyrimidine availability. | ||||||