I-TAC Activators
I-TAC activators encompass a variety of chemical compounds that facilitate the functional enhancement of I-TAC through diverse and specific signaling pathways, ensuring a tailored approach to the modulation of I-TAC's role in chemotaxis and immune response. Compounds such as Forskolin and Isoproterenol exert their effects by elevating cAMP levels, which in turn activate PKA; this kinase phosphorylates substrates that can lead to an upsurge in I-TAC expression and its secretion. Similarly, PMA, as a PKC activator, and calcium ionophores like Ionomycin and A23187, initiate a cascade of intracellular events that culminate in the activation of kinases and phosphatases.
I-TAC activators are a diverse set of chemical compounds that enable the amplification of I-TAC's biological functions through distinct signaling pathways, ensuring a specific approach to the modulation of I-TAC's role in chemotactic signaling. Forskolin and Isoproterenol, by increasing intracellular cAMP, activate PKA, which can phosphorylate substrates leading to an elevation in I-TAC activity. PMA, acting as a PKC activator, and calcium ionophores like Ionomycin and A23187, spark off signaling cascades that culminate in the activation of calcium-dependent kinases and phosphatases, which can contribute to the upregulation of I-TAC activity. Prostaglandin E2, through its interactions with G protein-coupled receptors, also raises cAMP levels, which can then activate PKA and enhance I-TAC's role in inflammation and chemotaxis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as a diacylglycerol analog to activate protein kinase C (PKC), which can phosphorylate various substrates, leading to the activation of downstream pathways that can enhance the activity of I-TAC in chemotaxis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, activating protein kinase A (PKA). PKA then phosphorylates target proteins that can contribute to the increased expression and secretion of I-TAC, enhancing its chemotactic function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations, which can activate calcium-dependent kinases and phosphatases, leading to a signaling cascade that could upregulate I-TAC activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels, similarly triggering cascades that can enhance I-TAC activity through calcium-dependent pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 interacts with its G protein-coupled receptors to increase intracellular cAMP, which activates PKA and can result in the augmented activity of I-TAC by modulating cellular responses involved in inflammation and chemotaxis. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to its specific G protein-coupled receptors, which may lead to the activation of signaling pathways that enhance I-TAC activity, particularly in the context of chemotaxis and vascular regulation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its receptors, can activate phospholipase C, leading to increased intracellular calcium and PKC activation, which may indirectly enhance I-TAC activity in immune response modulation. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Niacin acts through its G protein-coupled receptor to increase intracellular cAMP, which can activate PKA and potentially lead to the enhancement of I-TAC's activity in its chemotactic roles. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, through alpha and beta-adrenergic receptors, can influence cAMP levels and downstream PKA activation, which may contribute to the enhanced activity of I-TAC, particularly in stress response mechanisms. | ||||||