I-TAC Antibody (R-15): sc-74094

I-TAC Antibody (R-15) is a rat monoclonal IgG2a antibody that detects I-TAC of mouse origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-I-TAC antibody (R-15) is available as the non-conjugated form. The interferon-inducible T cell α chemoattractant (I-TAC), also known as βR1, H174, SCYB9B, Scyb11 (mouse), IP-9, or CXCL11, is a crucial member of the CXC chemokine family, primarily expressed in interferon-gamma-treated astrocytes, monocytes, keratinocytes, bronchial epithelial cells, and neutrophils. The gene encoding I-TAC is located on human chromosome 4q21.2. I-TAC plays a significant role in immune responses by selectively attracting T lymphocytes through interaction with the CXCR-3 receptor, which is vital for recruiting immune cells to sites of inflammation. This recruitment is particularly important in inflammatory diseases characterized by activated T cells, as I-TAC helps orchestrate immune response and maintain tissue homeostasis. I-TAC, along with related proteins, the interferon-induced protein of 10 kDa (IP-10) and monokine induced by interferon-gamma (MIG), is essential for mediating immune system response to pathogens and regulating inflammation, making I-TAC a key target for research in immunology and therapeutic interventions.

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I-TAC Antibody (R-15) References:

1. Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene.  |  Tensen, CP., et al. 1999. Biochim Biophys Acta. 1446: 167-72. PMID: 10395932
2. Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.  |  Mach, F., et al. 1999. J Clin Invest. 104: 1041-50. PMID: 10525042
3. Expression of IFN-inducible T cell alpha chemoattractant by human endothelial cells is cyclosporin A-resistant and promotes T cell adhesion: implications for cyclosporin A-resistant immune inflammation.  |  Mazanet, MM., et al. 2000. J Immunol. 164: 5383-8. PMID: 10799902
4. Cloning, genomic sequence, and chromosome mapping of Scyb11, the murine homologue of SCYB11 (alias betaR1/H174/SCYB9B/I-TAC/IP-9/CXCL11).  |  Meyer, M., et al. 2000. Cytogenet Cell Genet. 88: 278-82. PMID: 10828609
5. IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.  |  Albanesi, C., et al. 2000. J Immunol. 165: 1395-402. PMID: 10903743