IκB-ζ Inhibitors
The chemical class of IκB-ζ inhibitors encompasses a variety of compounds that target specific steps in the NF-κB signaling pathway, thereby modulating IκB-ζ activation and function. BAY 11-7082 is an inhibitor that directly blocks IκB-ζ phosphorylation, preventing its release and nuclear translocation. TPCA-1 inhibits IKK-2, an upstream kinase involved in IκB-ζ phosphorylation, thereby indirectly modulating IκB-ζ activity. sc-514, a selective COX-2 inhibitor, indirectly affects IκB-ζ by modulating the COX-2/PGE2 pathway, leading to reduced activation of the NF-κB signaling cascade. JSH-23 disrupts the nuclear translocation of NF-κB subunits, including IκB-ζ, and impedes its role in gene expression. Natural compounds like Withaferin A and Wedelolactone inhibit NF-κB activation, impacting IκB-ζ-mediated signaling.
Bay 11-7085, an analog of BAY 11-7082, shares similar inhibitory effects on NF-κB activation and IκB-ζ phosphorylation. Parthenolide and Andrographolide, natural products with anti-inflammatory effects, inhibit NF-κB activation, indirectly affecting IκB-ζ-mediated signaling. Celastrol, another natural product, modulates IκB-ζ by inhibiting the NF-κB pathway. Dehydroxymethylepoxyquinomicin inhibits proteasome function, blocking the degradation of IκB-ζ and leading to its cytoplasmic retention. QNZ (EVP4593), a potent NF-κB inhibitor, indirectly modulates IκB-ζ by inhibiting its phosphorylation and subsequent degradation. These inhibitors, with their diverse modes of action, provide valuable tools for dissecting the complex regulatory mechanisms governing IκB-ζ function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Inhibitor of NF-κB activation. BAY 11-7082 blocks IκB-ζ phosphorylation and subsequent degradation, preventing its release and nuclear translocation. This disrupts the activation of target genes mediated by IκB-ζ and the NF-κB signaling pathway. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $130.00 | 12 | |
Inhibitor of IKK-2, an upstream activator of IκB-ζ. TPCA-1 suppresses the phosphorylation of IκB-ζ by inhibiting IKK-2, leading to the sequestration of IκB-ζ in the cytoplasm and preventing its nuclear translocation. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $66.00 $89.00 | 13 | |
Selective COX-2 inhibitor that indirectly impacts IκB-ζ. SC-514 modulates the COX-2/PGE2 pathway, leading to reduced activation of the NF-κB signaling cascade and subsequent inhibition of IκB-ζ release and nuclear translocation. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
Inhibitor of nuclear translocation of NF-κB subunits, including IκB-ζ. JSH-23 disrupts the interaction between NF-κB and importin-α, preventing nuclear translocation and subsequent activation of target genes by IκB-ζ. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Natural compound with anti-inflammatory properties. Withaferin A inhibits the NF-κB pathway, leading to decreased IκB-ζ activation and nuclear translocation. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $108.00 $330.00 | 8 | |
Natural inhibitor of IκB-ζ. Wedelolactone suppresses IκB-ζ expression and nuclear translocation, inhibiting its role in NF-κB signaling. | ||||||
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $122.00 $516.00 | 55 | |
Analog of BAY 11-7082 with similar inhibitory effects on NF-κB activation. Bay 11-7085 disrupts the phosphorylation of IκB-ζ and its subsequent release, preventing nuclear translocation and downstream NF-κB-mediated gene expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Sesquiterpene lactone with anti-inflammatory properties. Parthenolide inhibits NF-κB activation, indirectly affecting IκB-ζ-mediated signaling by preventing its release and nuclear translocation. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
Natural product with anti-inflammatory effects. Andrographolide inhibits NF-κB activation, indirectly modulating IκB-ζ-mediated signaling by preventing its release and nuclear translocation. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Triterpenoid with anti-inflammatory properties. Celastrol inhibits the NF-κB pathway, affecting IκB-ζ activation and preventing its nuclear translocation. | ||||||