I-309 Activators
I-309 activators refer to a specific class of chemicals that modulate the activity of the chemokine protein known as I-309, which is encoded by the CCL1 gene in humans. This protein belongs to a larger family of chemoattractant cytokines that play roles in immunoregulatory and inflammatory processes by directing the migration of immune cells to sites of inflammation, infection, or tissue injury.
Direct activators of I-309 interact with the protein on a molecular level, possibly binding to its active sites and inducing a conformational change that increases its binding affinity to its receptor, CCR8. By doing so, these activators can enhance the chemotactic properties of I-309, leading to a more robust mobilization and activation of immune cells, such as T cells and monocytes. The activation of I-309 could also lead to the amplification of signal transduction pathways downstream of its receptor, resulting in a heightened cellular response. Indirect activators of I-309 might not interact with the protein itself but could enhance its activity or expression through various cellular mechanisms. For instance, they might upregulate the transcription of the CCL1 gene, leading to increased production of I-309. Alternatively, they could inhibit the degradation of I-309, resulting in a higher concentration of the active protein in the cellular environment. Indirect activators might also influence the post-translational modification of I-309, such as glycosylation patterns, which can affect the stability and bioactivity of the chemokine.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, thereby increasing intracellular levels of cAMP. Increased cAMP levels can stimulate the signaling pathways downstream of the CCR8 receptor, which is the known receptor for CCL1/I-309, leading to its activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 is a potent activator of the EP2 and EP4 receptors, which are known to increase the intracellular cAMP levels. This can enhance the CCR8 signaling pathway, leading to the activation of CCL1/I-309. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist, leading to elevated cAMP levels. This can stimulate the CCR8 signaling pathway, thereby activating CCL1/I-309. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, which results in an increase in intracellular cAMP levels. Elevated cAMP levels can enhance the signaling pathways downstream of the CCR8 receptor, leading to the activation of CCL1/I-309. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can interact with several G-protein coupled receptors, influencing cAMP levels. This impact on cAMP levels can modulate the CCR8 signaling pathway, leading to the activation of CCL1/I-309. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine interacts with G-protein coupled receptors, including H1 and H2, leading to changes in cAMP levels. This can stimulate the CCR8 signaling pathway, leading to the activation of CCL1/I-309. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine modulates various adenosine receptors, which can influence cAMP levels. This modulation can stimulate the CCR8 signaling pathway, leading to the activation of CCL1/I-309. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits cAMP phosphodiesterase, leading to increased intracellular cAMP levels. Elevated cAMP levels can stimulate the signaling pathways downstream of the CCR8 receptor, leading to the activation of CCL1/I-309. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is an adrenergic receptor agonist, which can increase cAMP levels. This increase can enhance the signaling pathways downstream of the CCR8 receptor, leading to the activation of CCL1/I-309. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine can stimulate beta-adrenergic receptors, leading to increased cAMP levels. This increase can stimulate the CCR8 signaling pathway, thereby activating CCL1/I-309. | ||||||