Date published: 2026-8-1

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Histamine, free base (CAS 51-45-6)

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Alternate Names:
1H-Imidazole-4-ethanamine; Ergotidine; 2-(4-Imidazolyl)ethylamine
Application:
Histamine, free base is a compound that activates NOS which results in the release of NO
CAS Number:
51-45-6
Purity:
≥96%
Molecular Weight:
111.15
Molecular Formula:
C5H9N3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Histamine is a potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.


Histamine, free base (CAS 51-45-6) References

  1. Structural and vibrational study of the tautomerism of histamine free-base in solution.  |  Ramírez, FJ., et al. 2003. J Am Chem Soc. 125: 2328-40. PMID: 12590563
  2. Selective determination of histamine by flow injection analysis.  |  Hungerford, JM., et al. 1990. Anal Chem. 62: 1971-6. PMID: 2240576
  3. Detection of histamine in human placental perfusate and the effect of histamine releasers.  |  Kohler, FW., et al. 1988. Res Commun Chem Pathol Pharmacol. 61: 185-200. PMID: 2460906
  4. Hyperosmolarity but not histamine evokes secretion of nasal fluid in the rat.  |  Petersson, G., et al. 1989. Eur J Pharmacol. 161: 37-43. PMID: 2566487
  5. Histamine selective microelectrode based on a synthetic organic liquid ion exchanger.  |  Bi, Y. 1989. Biosensors. 4: 373-80. PMID: 2818654
  6. pH-induced conformational changes in histamine in the solid state.  |  Kodchakorn, K., et al. 2019. RSC Adv. 9: 19375-19389. PMID: 35519396
  7. Experimental allergic orchitis in mice. II. Association of disease susceptibility with the locus controlling Bordetella pertussis-induced sensitivity to histamine.  |  Teuscher, C. 1985. Immunogenetics. 22: 417-25. PMID: 4065933
  8. The complexing of histamine with p-benzoquinone.  |  Moxon, GH. and Slifkin, MA. 1972. Biochim Biophys Acta. 286: 98-102. PMID: 4659269
  9. Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. I. In vivo and in vitro effects of the amines.  |  Rothwell, TL., et al. 1974. Int Arch Allergy Appl Immunol. 46: 1-13. PMID: 4814291
  10. Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes.  |  Linthicum, DS. and Frelinger, JA. 1982. J Exp Med. 156: 31-40. PMID: 6806429
  11. Quality control of phenylbutazone II: Analysis of phenylbutazone and its decomposition products in drugs by high-pressure liquid chromatography.  |  Fabre, H., et al. 1982. J Pharm Sci. 71: 120-2. PMID: 7057365
  12. Relaxant responses of the isolated guinea-pig left pulmonary artery produced by acidic histamine solutions.  |  Hand, JM. and Buckner, CK. 1981. Eur J Pharmacol. 70: 225-30. PMID: 7262186
  13. Boophilus microplus: the effect of histamine on the attachment of cattle-tick larvae--studies in vivo and in vitro.  |  Kemp, DH. and Bourne, A. 1980. Parasitology. 80: 487-96. PMID: 7393620
  14. Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors.  |  Fleckenstein, AE., et al. 1993. Naunyn Schmiedebergs Arch Pharmacol. 347: 50-4. PMID: 8446183
  15. Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.  |  Sudweeks, JD., et al. 1993. Proc Natl Acad Sci U S A. 90: 3700-4. PMID: 8475118

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Histamine, free base, 1 g

sc-204000
1 g
$94.00

Histamine, free base, 5 g

sc-204000A
5 g
$283.00

Histamine, free base, 25 g

sc-204000B
25 g
$988.00