HUGT2 Activators
HUGT2, also known as UDP-Glucose:Glycoprotein Glucosyltransferase 2, is an enzyme that plays a fundamental role in the quality control system of protein folding within the endoplasmic reticulum (ER). The ER is a cellular organelle responsible for the proper folding of proteins, a process that is vital for protein function.HUGT2 is part of the glycoprotein folding cycle, where it adds a glucose moiety to misfolded glycoproteins, enabling them to interact with the lectin chaperones calnexin and calreticulin. These chaperones assist in the correct folding of proteins. If a protein fails to fold correctly after multiple cycles, it is targeted for degradation to inhibit the accumulation of misfolded proteins, which can be harmful to the cell.
The activity of HUGT2 is essential for maintaining cellular protein homeostasis and inhibiting ER stress, a condition that arises from the accumulation of misfolded proteins and can trigger cell death if not resolved. ER stress is implicated in a variety of diseases, including neurodegenerative disorders, diabetes, and cancer.In addition to protein folding, the enzyme HUGT2 can also influence other biological processes due to its role in glycosylation, a modification that can affect the stability, localization, and function of proteins.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-saccharic acid calcium salt tetrahydrate | 5793-89-5 | sc-205336 sc-205336A | 25 g 100 g | $139.00 $373.00 | 1 | |
May enhance glucuronidation, potentially impacting HUGT2 activity by influencing the availability of glucuronic acid. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Found in cruciferous vegetables, it can modulate phase II detoxification enzymes, potentially influencing HUGT2. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
A compound in cruciferous vegetables, known to affect phase II detoxifying enzymes, which may include HUGT2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known for its effect on various metabolic pathways, potentially influencing HUGT2 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Can modulate several metabolic pathways, potentially affecting HUGT2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that impacts various metabolic enzymes, potentially influencing HUGT2 activity. | ||||||
β-D-Galactose pentaacetate | 4163-60-4 | sc-257284 sc-257284A sc-257284B sc-257284C sc-257284D | 25 g 100 g 250 g 1 kg 2.5 kg | $45.00 $80.00 $170.00 $520.00 $1270.00 | ||
May support glucuronidation, potentially impacting HUGT2 activity. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Found in certain fruits and nuts, it can influence metabolic pathways, potentially impacting HUGT2. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
A flavonoid that can modulate metabolic enzyme activity, potentially affecting HUGT2. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Known for its liver-protective and enzyme-modulating effects, potentially affecting HUGT2. | ||||||