HSV-2 gD Inhibitors
The class of chemicals known as HSV-2 gD Inhibitors encompasses a range of antiviral agents that target various stages of the herpes simplex virus lifecycle, from DNA synthesis to viral entry. These compounds, through their different mechanisms of action, aim to reduce the expression or function of gD, thereby inhibiting its critical role in mediating the entry of HSV-2 into host cells.
The action of these inhibitors can be direct, such as in the case of Docosanol, which impedes the fusion process between the virus and the host cell, or indirect, where the focus is on reducing overall viral replication and protein synthesis, as seen with Acyclovir, Valacyclovir, and others. By limiting viral replication, these compounds can lead to a decrease in the levels of viral proteins, including gD, thus hindering the virus's ability to successfully infect host cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acyclovir | 59277-89-3 | sc-202906 sc-202906A | 50 mg 500 mg | $147.00 $922.00 | 2 | |
Acyclovir targets HSV viral DNA polymerase, inhibiting viral replication. Reduced viral replication can lead to decreased expression of gD, thereby inhibiting its function in viral entry. | ||||||
Valacyclovir Hydrochloride | 124832-27-5 | sc-204937 sc-204937A | 50 mg 100 mg | $117.00 $150.00 | ||
As a prodrug of acyclovir, Valacyclovir has a similar mechanism, potentially reducing gD levels by inhibiting viral replication. | ||||||
Foscarnet sodium | 63585-09-1 | sc-205330 sc-205330A | 1 g 5 g | $186.00 $663.00 | ||
Foscarnet inhibits viral DNA polymerase, thereby potentially decreasing gD expression by limiting viral replication and protein synthesis. | ||||||
Trifluorothymidine | 70-00-8 | sc-222370 sc-222370A | 100 mg 1 g | $179.00 $500.00 | 1 | |
Trifluridine interferes with viral DNA synthesis, which could result in lower levels of gD and its associated functions in viral entry. | ||||||
Cidofovir | 113852-37-2 | sc-482141 | 50 mg | $135.00 | ||
Cidofovir's inhibition of viral DNA polymerase may lead to reduced synthesis of viral proteins including gD, hindering its role in cell entry. | ||||||
Idoxuridine | 54-42-2 | sc-205720 sc-205720A | 500 mg 1 g | $102.00 $209.00 | ||
Idoxuridine disrupts viral DNA synthesis, potentially leading to decreased production of gD and impairment of its function in viral entry. | ||||||
Penciclovir | 39809-25-1 | sc-203183 | 100 mg | $255.00 | ||
Penciclovir can reduce viral replication, potentially resulting in lower gD levels and inhibiting its function in the viral lifecycle. | ||||||
Famciclovir | 104227-87-4 | sc-211498 | 100 mg | $123.00 | ||
Famciclovir, a prodrug of penciclovir, can similarly impact HSV replication and potentially reduce the expression and function of gD. | ||||||
Ganciclovir | 82410-32-0 | sc-203963 sc-203963A | 50 mg 250 mg | $228.00 $413.00 | 1 | |
Ganciclovir targets viral replication, which may lead to decreased gD expression and hinder its role in facilitating viral entry into host cells. | ||||||
Brivudine | 69304-47-8 | sc-205607 sc-205607A sc-205607B sc-205607C | 10 mg 25 mg 100 mg 1 g | $220.00 $460.00 $1000.00 $2100.00 | 4 | |
Brivudine can potentially reduce gD expression by affecting viral DNA synthesis and replication. | ||||||