Molecular structure of Penciclovir, CAS Number: 39809-25-1
Penciclovir (CAS 39809-25-1)
Alternate Names:
2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin- 6-one
Application:
Penciclovir is a purine acyclic nucleoside analogue with potent antiviral activity
CAS Number:
39809-25-1
Purity:
≥98%
Molecular Weight:
253.26
Molecular Formula:
C10H15N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Penciclovir is a purine acyclic nucleoside analogue with potent antiviral activity. The compound has been used in Human Herpesvirus 6 studies and its activity assessed through flow cytometry. Herpes simplex virus-1 studies indicate that Penciclovir induces apoptosis without causing much genotoxicity.Penciclovir, also referred to as BRL-39123, exhibits low toxicity and favorable selectivity as a nucleoside analogue.
Penciclovir (CAS 39809-25-1) References
- Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches. | Thust, R., et al. 2000. Cancer Gene Ther. 7: 107-17. PMID: 10678363
- Flow cytometric evaluation of antiviral agents against human herpesvirus 6. | Amjad, M., et al. 2001. Microbiol Immunol. 45: 233-40. PMID: 11345533
- Penciclovir for the treatment of herpes simplex labialis: a review. | Randolph, B. 2001. ASDC J Dent Child. 68: 189-90. PMID: 11693011
- Susceptibilities of herpes simplex viruses to penciclovir and acyclovir in eight cell lines. | Leary, JJ., et al. 2002. Antimicrob Agents Chemother. 46: 762-8. PMID: 11850259
- Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy. | Bacon, TH., et al. 2003. Clin Microbiol Rev. 16: 114-28. PMID: 12525428
- Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery. | Lv, Q., et al. 2009. Int J Pharm. 372: 191-8. PMID: 19429280
- Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients. | Meira, RZC., et al. 2019. Materials (Basel). 12: PMID: 31569620
- Modifications on the heterocyclic base of ganciclovir, penciclovir, acyclovir - syntheses and antiviral properties. | Chuchkov, K., et al. 2020. Nucleosides Nucleotides Nucleic Acids. 39: 979-990. PMID: 32312162
- Emergence of varicella-zoster virus resistance to acyclovir: epidemiology, prevention, and treatment. | Shiraki, K., et al. 2021. Expert Rev Anti Infect Ther. 19: 1415-1425. PMID: 33853490
- A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase. | Zhao, J., et al. 2021. Antiviral Res. 190: 105078. PMID: 33894278
- Oral gel loaded with penciclovir-lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis. | Hosny, KM., et al. 2021. Drug Deliv. 28: 1043-1054. PMID: 34060397
- Suramin, penciclovir, and anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2. | Dey, SK., et al. 2022. J Biomol Struct Dyn. 40: 14067-14083. PMID: 34784490
- Rapid determination of acyclovir, its main metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum using LC-MS/MS. | Ärlemalm, A., et al. 2022. Biomed Chromatogr. 36: e5315. PMID: 34981553
- Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells. I. Purine nucleoside analogues. | Thust, R., et al. 1996. Antiviral Res. 31: 105-13. PMID: 8793014
Inhibitor of:
CMV UL94, CNT1, DGUOK, HHV-8 K14, HSV-1, HSV-1 gB, HSV-1 Glycoprotein D, HSV-1 ICP0, HSV-1 ICP4, HSV-1 UL42, HSV-2, HSV-2 gD, HSV-2 gE Envelope Protein, HSV-2 gG Envelope Protein, HSV-2 ICP8 Major DNA binding protein, MAdCAM-1, Varicella Zoster Virus gpI, Varicella Zoster Virus gpIII, Varicella Zoster Virus IV, VZV IE62, and VZV thymidine kinase.Activator of:
HSV-1 gG, HSV-1 ICP4 Immediate Early Protein, HSV-1 Thymidine Kinase, HSV-1 VP22, HSV-2 gG, HSV-2 VP22, and Varicella Zoster Virus gpIV.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Penciclovir, 100 mg | sc-203183 | 100 mg | $255.00 |