HSV-1 VP22 Inhibitors
HSV-1 VP22 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the Herpes Simplex Virus 1 (HSV-1) Virion Protein 22 (VP22). VP22 is a multifunctional protein encoded by the HSV-1 genome, and it plays a crucial role in various aspects of the virus's life cycle. One of its notable functions is its involvement in the intercellular spread of herpesviruses. VP22 facilitates the transfer of viral proteins and nucleic acids between infected and uninfected cells, promoting efficient viral dissemination. Inhibitors of HSV-1 VP22 are developed to interact with this viral protein, disrupting its functions related to viral spread and intercellular trafficking.
Typically, HSV-1 VP22 inhibitors are small molecules or compounds designed to bind to VP22, interfering with its interactions with other viral and cellular components. By doing so, these inhibitors may hinder the proper assembly and release of herpesvirus particles and the efficient transfer of viral components to neighboring cells. Research into HSV-1 VP22 inhibitors is vital for gaining a better understanding of the molecular mechanisms underlying herpesvirus replication and dissemination. This knowledge may contribute to the development of strategies aimed at disrupting the viral life cycle and controlling HSV-1 infection.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a tetracyclic diterpene that inhibits DNA polymerase, potentially reducing VP22 expression by hindering viral DNA synthesis. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin, a polysulfonated naphthylurea, inhibits various enzymes and could affect VP22 by altering cellular and viral processes. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
AZT is a thymidine analog that interferes with DNA synthesis, potentially diminishing the replication of HSV-1 and hence VP22 levels. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Fludarabine is a nucleotide analog that can inhibit DNA synthesis, possibly reducing the expression of viral proteins like VP22. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which might influence HSV-1 infection dynamics and VP22 expression. | ||||||
Sinefungin | 58944-73-3 | sc-203263 sc-203263B sc-203263C sc-203263A | 1 mg 100 mg 1 g 10 mg | $266.00 $5100.00 $39576.00 $690.00 | 4 | |
Sinefungin is a natural adenosylmethionine decarboxylase inhibitor, which may affect viral methyltransferases and VP22 production. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Ribavirin inhibits inosine monophosphate dehydrogenase, possibly affecting HSV-1 replication and VP22 levels. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine has been shown to inhibit clathrin-mediated endocytosis, which could impact HSV-1 entry and subsequent VP22 expression. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, potentially affecting HSV-1 transport within the host cell and influencing VP22 levels. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $180.00 $620.00 | 10 | |
An inhibitor of glucosidase I, castanospermine might alter glycosylation of viral proteins, affecting HSV-1 replication and VP22 expression. | ||||||