HSPC121 Activators
HSPC121 Activators are a diverse set of chemical compounds that indirectly enhance the functional activity of HSPC121 through various biochemical mechanisms. Geldanamycin and its analog 17-AAG, by inhibiting the chaperone activity of Hsp90, indirectly necessitate an increased role for HSPC121 in protein folding and maintenance, which can lead to enhanced activity of HSPC121 as part of a compensatory cellular response. Similarly, Radicicol and Novobiocin, which target the ATPase and C-terminal domains of Hsp90, respectively, contribute to this enhanced demand for the co-chaperone activity of HSPC121. Celastrol, through the activation of HSF1, can potentiate the heat shock response, leading to an increase in HSPC121's activity as part of the cell's defense mechanism against protein-damaging stress. The proteasome inhibitor MG-132 causes an accumulation of misfolded proteins, which in turn drives the need for more HSPC121 activity to assist in protein refolding or degradation pathways.
Additionalactivators include Coniferyl aldehyde and Quercetin, which activate HSF1, and Withaferin A, which disrupts Hsp90 function, all of which can lead to an upsurge in HSPC121 activity to counter misfolded proteins. Physical stress, such as Heat Shock, and chemical stress inducers like Sodium Arsenite, trigger the heat shock response, thus enhancing the expression and activity of HSPC121 as a protective measure. The release of zinc from Zinc Metallothionein during cellular stress also activates HSF1, which subsequently upregulates HSPC121, further promoting its chaperoning capabilities within the cell. Collectively, these activators leverage different aspects of the cellular stress response and proteostasis mechanisms to enhance the functional activity of HSPC121, ensuring that the protein's co-chaperone action is amplified to meet the increased cellular demands.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin binds specifically to heat shock protein 90 (Hsp90) and inhibits its chaperone activity. Since HSPC121 is a co-chaperone of Hsp90, geldanamycin-mediated inhibition of Hsp90 can increase the need for HSPC121 activity in the cell. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is an analog of geldanamycin that also binds to Hsp90, inhibiting its function. This inhibition can lead to a compensatory upregulation of HSPC121 and its co-chaperone activity. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $90.00 $326.00 | 13 | |
Radicicol is another Hsp90 inhibitor that, by binding to the ATPase domain of Hsp90, can disrupt its activity. This disruption can indirectly enhance the functional activity of HSPC121 by compensatory mechanisms. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $96.00 $355.00 | ||
Novobiocin is a coumarin antibiotic that binds to the C-terminal domain of Hsp90, which can destabilize its interaction with co-chaperones. This may lead to an increased requirement for HSPC121's chaperone activity. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol is a quinone methide triterpenoid that can induce heat shock response by activating heat shock factor 1 (HSF1), potentially increasing the expression and activity of HSPC121 as part of the stress response. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of misfolded proteins, thereby increasing the demand for molecular chaperones like HSPC121 to refold or degrade these proteins. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that can induce the heat shock response and thereby potentially increase the functional activity of HSPC121 through upregulation as part of the cellular protective mechanisms. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A is a steroidal lactone that can disrupt the normal function of Hsp90 by binding to its N-terminal domain. This disruption could indirectly lead to enhanced activity of HSPC121 due to the need for additional chaperone support. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium Arsenite is an inducer of the heat shock response which can lead to the upregulation of heat shock proteins such as HSPC121, enhancing its protective role against protein misfolding and aggregation. | ||||||