HSPC121 Inhibitors
HSPC121 inhibitors represent a class of chemical compounds designed to specifically target and impede the activity of the HSPC121 protein. HSPC121, a molecular chaperone, plays a critical role in the proper folding and functioning of other proteins. By preventing the misfolding of proteins, HSPC121 ensures cellular homeostasis and is implicated in various essential cellular processes. Inhibitors of this protein interfere with its chaperone activity, leading to a cascade of effects within the cell that result from the accumulation of misfolded proteins. The inhibition of HSPC121 can induce a stress response within the cell, known as the heat shock response, which attempts to rectify the imbalance caused by the accumulation of improperly folded proteins. This response activates a set of genes that encode for heat shock proteins (HSPs) which work to counteract the protein misfolding. HSPC121 inhibitors are thus crucial in modulating the cellular pathways related to protein folding, and their action can have profound effects on the cellular proteostasis network.
The specific mechanism of action of HSPC121 inhibitors can vary depending on their chemical structure, but they generally function by binding to the active site or regulatory regions of the HSPC121 protein, thereby altering its conformation and function. This binding can inhibit the ATPase activity of HSPC121, which is necessary for its chaperone action, preventing the protein from undergoing the necessary conformational changes required to assist in protein folding. As a result, the normal function of HSPC121 is compromised, leading to a build-up of non-native proteins that can disrupt cellular function. The chemical compounds that act as HSPC121 inhibitors might also influence the expression levels of HSPC121 by interfering with the transcriptional pathways or signaling mechanisms that regulate the synthesis of this protein. By influencing the protein's expression and activity, HSPC121 inhibitors play a crucial role in the regulation of cellular protein homeostasis, unfolding pathways, and stress responses, all of which are vital for maintaining the proper functioning of biological systems at the cellular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora kinase A inhibitor. Aurora kinase A is crucial for the proper functioning of the mitotic spindle. By inhibiting this kinase, Alisertib can disrupt the mitotic process, which is vital for cell division and proliferation. This inhibition can indirectly lead to a reduced level of HSPC121 by limiting the population of cells where HSPC121 is typically upregulated during cell division. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and as a result, inhibits their disassembly, leading to cell cycle arrest at the G2/M phase. HSPC121 is known to be associated with cell proliferation; thus, paclitaxel indirectly decreases HSPC121 activity by halting cell cycle progression where HSPC121 might be active. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that increases acetylation of histones, leading to altered gene expression. This can result in the downregulation of genes involved in cell cycle progression, thereby potentially decreasing HSPC121 expression in rapidly dividing cells. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that impedes the mTOR pathway, which plays a role in cell growth and proliferation. Inhibition of mTOR could lead to a decrease in the population of cells where HSPC121 is upregulated due to its association with proliferative processes. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a tyrosine kinase inhibitor with activity against Raf kinases. By inhibiting Raf kinases, Sorafenib hampers the downstream MAPK/ERK signaling, which is implicated in cell proliferation and survival, potentially reducing HSPC121 levels in cells reliant on this pathway for survival and division. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor that targets BCR-ABL, c-KIT, and PDGFR. Since HSPC121 may be implicated in signaling pathways involving these kinases, Imatinib could indirectly decrease HSPC121 function by disrupting these signaling cascades. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that prevents the degradation of proteins tagged for destruction. By disrupting normal proteostasis, Bortezomib can influence cell cycle progression and survival pathways, thus indirectly affecting HSPC121 levels in proliferating cells. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide, through its antiangiogenic and immunomodulatory effects, can alter the tumor microenvironment, indirectly affecting the expression and function of HSPC121 in cells within that environment, particularly those undergoing rapid division or stress responses. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $49.00 $367.00 $2030.00 | 18 | |
Lenalidomide is an analog of thalidomide with similar but more potent effects. It can modulate the tumor microenvironment and immune response, potentially leading to decreased expression or activity of HSPC121 in affected cells. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is an autophagy inhibitor that can prevent the degradation of cellular components within lysosomes. This can lead to cellular stress and may impact the expression of stress response proteins such as HSPC121. | ||||||