HSPA14 Activators
Given the nature of HSPA14 as a heat shock protein, it is logical to deduce that chemicals causing cellular stress might indirectly enhance its functional activity. For instance, Salubrinal, a selective inhibitor of eIF2α dephosphorylation, leads to accumulation of unfolded proteins, which in turn could necessitate increased activity of chaperone proteins such as HSPA14. Similarly, Eeyarestatin I, which inhibits ER-associated protein degradation (ERAD), could increase the demand for HSPA14 activity by causing an accumulation of misfolded proteins in the ER.
Moreover, disruption in protein transport from the ER to the Golgi apparatus by Brefeldin A could potentially increase the demand for HSPA14. Other compounds, like methotrexate and azetidine-2-carboxylic acid, which disrupt DNA synthesis and repair, or lead to the incorporation of incorrect amino acids into proteins, respectively, could potentially increase the demand for HSPA14. This logical analysis, although based on the known functions of HSPA14, should be validated by further experimental studies.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal is a selective inhibitor of eIF2α dephosphorylation. By inhibiting this process, it can lead to the accumulation of unfolded proteins, thus increasing the need for chaperone proteins like HSPA14. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Eeyarestatin I inhibits ER-associated protein degradation (ERAD), a process that HSPA14 could be involved in, leading to an increased demand for HSPA14 activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts protein transport from the ER to the Golgi apparatus, potentially increasing the need for chaperone proteins like HSPA14. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic acid induces ER stress by inhibiting the SERCA pump, disrupting calcium homeostasis and potentially increasing the need for HSPA14 activity. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
Nelfinavir is a protease inhibitor that can cause misfolded proteins to accumulate, potentially increasing the demand for chaperone proteins like HSPA14. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, disrupting DNA synthesis and repair, and potentially increasing the need for chaperone proteins like HSPA14. | ||||||
L-Azetidine-2-carboxylic acid | 2133-34-8 | sc-263441 sc-263441A | 1 g 5 g | $139.00 $421.00 | 1 | |
Azetidine-2-carboxylic acid is incorporated into proteins in place of proline, leading to misfolded proteins and potentially increasing the demand for chaperone proteins like HSPA14. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
Deoxynojirimycin inhibits N-linked glycosylation, a common post-translational modification, potentially increasing the need for chaperone proteins like HSPA14. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid is a bile acid that can protect cells from ER stress, potentially influencing the demand for chaperone proteins like HSPA14. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $102.00 $468.00 $832.00 $4162.00 $7283.00 | 2 | |
Guanabenz selectively enhances the integrated stress response, a pathway that HSPA14 could be involved in, and could thereby increase the demand for HSPA14 activity. | ||||||