HSP 90 Activators
The class of chemicals called HSP90 activators includes compounds that can indirectly modulate the activity of HSP90 by affecting its ATPase function, binding to its N-terminal domain or ATP-binding pocket, and promoting the degradation of client proteins. These activators, such as geldanamycin, radicicol, and their derivatives, interfere with the chaperone function of HSP90, leading to the destabilization and degradation of client proteins that rely on HSP90 for their proper folding and function. Other compounds, such as novobiocin, EGCG, and curcumin, can indirectly modulate HSP90 activity by affecting its ATPase function and influencing the stability of client proteins.
By targeting HSP90, these chemicals have the potential to disrupt key cellular processes that rely on HSP90-mediated protein folding and stabilization. HSP90 is involved in the maturation and stability of various client proteins, including kinases, transcription factors, and steroid hormone receptors. Its inhibition can lead to the degradation of these client proteins, thereby influencing signaling pathways involved in cell growth, survival, and stress response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $92.00 $333.00 | 13 | |
Radicicol is a natural product that binds to the N-terminal domain of HSP90 and inhibits its ATPase activity, leading to the degradation of client proteins. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is a synthetic derivative of geldanamycin that binds to the N-terminal domain of HSP90, disrupting its function and promoting client protein degradation. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $128.00 $380.00 | ||
Novobiocin is an antibiotic that can indirectly modulate HSP90 activity by inhibiting its ATPase activity, destabilizing client proteins, and affecting HSP90-mediated cellular processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a natural polyphenol found in green tea that can disrupt HSP90 function by binding to its ATP-binding pocket, leading to client protein degradation. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a natural compound found in Withania somnifera that can bind to HSP90 and inhibit its function, leading to the degradation of client proteins. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid compound that can indirectly modulate HSP90 activity by affecting its ATPase function and influencing the stability of client proteins. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound found in turmeric that can indirectly modulate HSP90 activity by affecting its ATPase function and influencing the stability of client proteins. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol is a natural compound found in Tripterygium wilfordii that can bind to HSP90, disrupt its function, and promote client protein degradation. | ||||||