HSP90 Antibody (4F10): sc-69703

HSP 90 Antibody (4F10) is a mouse monoclonal IgG2b antibody that detects HSP 90 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HSP 90 antibody (4F10) is available as a non-conjugated format. HSP 90 protein plays a crucial role as a molecular chaperone, assisting in the proper folding and stabilization of various client proteins, including steroid hormone receptors and kinases, which are vital for cellular signaling and stress responses. HSP 90′s ability to form complexes with other proteins, such as the glucocorticoid receptor and various kinases, underscores its significance in maintaining cellular homeostasis and regulating key signaling pathways. Through facilitating correct protein conformation, HSP 90 ensures functionality and provides protection during cellular stress, making HSP 90 a critical target for therapeutic interventions aimed at modulating stress responses in disease contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

HSP90 Antibody (4F10) References:

1. PKC epsilon is a unique regulator for hsp90 beta gene in heat shock response.  |  Wu, JM., et al. 2003. J Biol Chem. 278: 51143-9. PMID: 14532285
2. HSP90 and the chaperoning of cancer.  |  Whitesell, L. and Lindquist, SL. 2005. Nat Rev Cancer. 5: 761-72. PMID: 16175177
3. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.  |  Cowen, LE. and Lindquist, S. 2005. Science. 309: 2185-9. PMID: 16195452
4. Modulating molecular chaperone Hsp90 functions through reversible acetylation.  |  Aoyagi, S. and Archer, TK. 2005. Trends Cell Biol. 15: 565-7. PMID: 16199163
5. The HSP90 family of genes in the human genome: insights into their divergence and evolution.  |  Chen, B., et al. 2005. Genomics. 86: 627-37. PMID: 16269234
6. Hsp90: a chaperone for protein folding and gene regulation.  |  Zhao, R. and Houry, WA. 2005. Biochem Cell Biol. 83: 703-10. PMID: 16333321
7. Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells.  |  Yang, K., et al. 2006. Mol Biol Cell. 17: 1461-71. PMID: 16394098
8. Substrate transfer from the chaperone Hsp70 to Hsp90.  |  Wegele, H., et al. 2006. J Mol Biol. 356: 802-11. PMID: 16403523
9. Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.  |  Allan, RK., et al. 2006. J Biol Chem. 281: 7161-71. PMID: 16421106

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSP90 Antibody (4F10) has 157 citations in a variety of scientific publications.

Primary antibodies like Anti-HSP90 Antibody (4F10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSP90 Antibody (4F10) Specifications

Alternate Product Name: HSP90

Product Clone Name: 4F10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: HSP 90

Epitope Species: human

Product Reactivity/Detection: HSP 90

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG_2b in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and < 1% glycerol

Research Citations: 157 citations in various scientific publications

Available Conjugates/Forms for HSP90 Antibody (4F10): N/A

The preferred HSP90 alpha/beta antibody is HSP90 alpha/beta Antibody (F-8): sc-13119.