HSH2 Inhibitors
HSH2 Inhibitors are chemicals that target specific pathways or processes that the HSH2 protein is presumed to be involved in, given its potential role in signal transduction. These compounds are not direct inhibitors of HSH2 but are theorized to interfere with the protein's activity through various indirect mechanisms.
The first group of inhibitors includes PI3K inhibitors like LY294002 and Wortmannin. These compounds prevent the formation of PIP3, a critical secondary messenger in many signaling pathways. By inhibiting PI3K, these compounds could reduce HSH2 activity if HSH2 is downstream of PI3K signaling. The MEK1/2 inhibitors U0126 and PD98059, along with the JNK inhibitor SP600125, target key kinases in the MAPK pathway. Inhibition of these kinases would likely lead to reduced activation of transcription factors such as AP-1, which may play a role in HSH2-mediated signaling. By disrupting these pathways, the activity of HSH2, if it is a downstream effector, would be decreased.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that prevents PIP3 formation, potentially inhibiting HSH2 activation downstream. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A MEK1/2 inhibitor that interrupts the MAPK/ERK pathway, which could decrease HSH2 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Another MEK inhibitor that could result in reduced HSH2-mediated signaling by inhibiting ERK activation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that might inhibit HSH2 activity by preventing AP-1 transcription factor activation. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $31.00 $128.00 $454.00 | 45 | |
A p38 MAPK inhibitor, potentially reducing HSH2's role in response to stress stimuli. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor that could decrease HSH2 activation by blocking PIP3-dependent signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that could downregulate HSH2 activity by inhibiting downstream signaling required for cell growth and proliferation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
A Src family kinase inhibitor that could reduce HSH2 activation by inhibiting upstream tyrosine kinase signaling. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
A SRC inhibitor that could decrease HSH2-mediated signaling pathways linked to cell proliferation and survival. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
An NF-κB pathway inhibitor that might indirectly inhibit HSH2 by reducing transcription of genes involved in inflammation and survival. | ||||||