HRT1_Hrt1 Activators
Activators of HEY1 can be broadly classified into compounds that target the Notch signaling pathway and those that modulate other pathways with downstream effects on HEY1 transcription. These activators function by various mechanisms, such as mimicking natural ligands of the Notch receptor, modulating enzyme activity to favor the Notch pathway activation, or influencing other signaling pathways that have crosstalk with Notch signaling. For example, molecules like SAG can act as a ligand to the Notch receptor or its downstream components, directly influencing the pathway's activity and enhancing HEY1 expression. Other compounds, such as Valproic acid or Resveratrol, can indirectly influence HEY1 by modifying the chromatin state around the HEY1 gene or by adjusting the balance of signaling molecules that govern the intensity of Notch signaling, respectively.
Furthermore, small molecule activators such as 6-BIO or Anagrelide exert their effects by inhibiting enzymes that negatively regulate Notch pathway components or by elevating second messengers that can enhance the pathway's activation. The direct or indirect increase in the activity of the Notch pathway invariably leads to the upregulation of HEY1 transcription. As such, the regulation of HEY1 via chemical activators is not isolated but interconnected with an extensive network of signaling cascades. These compounds, in their respective capacities, harness the intricate web of cellular communications to upregulate HEY1 expression, emphasizing their significance in cellular and developmental biology research related to transcriptional regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is known to potentiate the Notch signaling pathway. It can increase the transcriptional activity of Notch target genes such as HEY1 by enhancing the acetylation of histones associated with the HEY1 promoter region. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $235.00 $260.00 | 4 | |
This compound is a potent and selective gamma-secretase modulator. By facilitating the cleavage of Notch receptors, it enhances the release of the NICD and its subsequent translocation to the nucleus, increasing HEY1 gene transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate sirtuin activity which has been linked to Notch pathway regulation. Its action can result in the upregulation of Notch signaling components, thereby promoting HEY1 expression. | ||||||
SAG | 912545-86-9 | sc-212905 sc-212905A | 1 mg 5 mg | $166.00 $421.00 | 27 | |
SAG activates the Hedgehog signaling pathway, which can interact with the Notch pathway to synergistically increase the expression of HEY1, especially in the context of developmental processes. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 Inhibitor IX leads to the stabilization of beta-catenin. Activated beta-catenin can upregulate Notch signaling, subsequently increasing HEY1 transcription. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C which has been associated with increased Notch receptor sensitivity, thus can enhance the transcriptional activation of HEY1 through the Notch pathway. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
Anagrelide increases cAMP levels in cells, which has been associated with upregulated Notch signaling, potentially leading to enhanced HEY1 expression. | ||||||
BMS-708163 | 1146699-66-2 | sc-364444 sc-364444A | 10 mg 50 mg | $480.00 $1455.00 | 1 | |
Although primarily a gamma-secretase inhibitor, BMS-708163 has been shown under certain conditions to enhance Notch signaling, potentially increasing HEY1 levels through feedback mechanisms. | ||||||
(±)-Hesperetin | 520-33-2 | sc-202647 | 1 g | $47.00 | 4 | |
(±)-Hesperetin is reported to increase Notch signaling. It can indirectly enhance the transcription of HEY1 by modulating pathway intermediates that lead to the activation of Notch signaling. | ||||||