HPV16 E7 Inhibitors
Common HPV16 E7 Inhibitors include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, (-)-Epigallocatechin Gallate CAS 989-51-5, Curcumin CAS 458-37-7, Quercetin CAS 117-39-5 and D,L-Sulforaphane CAS 4478-93-7.
HPV16 E7 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of the Human Papillomavirus Type 16 (HPV16) E7 protein. HPV16 is a high-risk type of human papillomavirus associated with various cancers, particularly cervical cancer. The E7 protein is a viral oncoprotein that plays a critical role in promoting cellular transformation and facilitating viral replication. It interacts with host cell proteins involved in cell cycle regulation and contributes to the evasion of host immune responses.
HPV16 E7 inhibitors work by specifically targeting the E7 protein, interfering with its interactions with host cell proteins and disrupting its oncogenic functions. By doing so, these inhibitors may modulate the cellular pathways affected by HPV16 E7 and impact the overall viral life cycle and for cellular transformation. Research into HPV16 E7 inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in understanding viral-host interactions. The study of HPV16 E7 inhibitors contributes to a deeper understanding of the intricate mechanisms underlying viral oncogenesis and cellular transformation processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid inhibits HPV16 E7 by interfering with its ability to interact with cellular proteins, ultimately preventing the disruption of cell cycle control and promoting apoptosis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) inhibits HPV16 E7 by targeting its interaction with key cellular proteins, inhibiting its ability to interfere with cell cycle regulation, and promoting the elimination of infected cells. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits HPV16 E7 by interfering with its interaction with cellular factors, disrupting its ability to promote cell cycle progression and inhibiting its oncogenic activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits HPV16 E7 by disrupting its interaction with cellular proteins, thus preventing its interference with cell cycle regulation and promoting the degradation of HPV-infected cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane inhibits HPV16 E7 by modulating its interaction with cellular proteins, preventing its interference with cell cycle control and promoting the clearance of HPV-infected cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol inhibits HPV16 E7 by targeting its interaction with key cellular proteins, inhibiting its ability to interfere with cell cycle regulation, and promoting the elimination of HPV-infected cells. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin inhibits HPV16 E7 by forming DNA adducts and inducing DNA damage, leading to cell cycle arrest and apoptosis in HPV-infected cells. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol inhibits HPV16 E7 by modulating its interaction with cellular proteins, disrupting its ability to interfere with cell cycle regulation, and promoting apoptosis in infected cells. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits HPV16 E7 by targeting cyclin-dependent kinases (CDKs), which are essential for cell cycle progression. By inhibiting CDKs, flavopiridol disrupts E7-mediated cell cycle dysregulation and promotes cell death. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin inhibits HPV16 E7 by disrupting its interaction with cellular chaperone proteins, leading to E7 protein degradation and inhibition of its oncogenic activity, resulting in decreased cell proliferation and survival. | ||||||