HOXA3 Inhibitors
HOXA3 inhibitors belong to a specialized class of chemical compounds designed to impede the activity of the HOXA3 gene. The HOXA3 gene is a member of the HOX gene family, which plays a crucial role in embryonic development and cellular differentiation. These inhibitors are meticulously designed to selectively target and modulate the function of HOXA3, exerting their effects at the molecular level. The HOXA3 gene is known for its involvement in the regulation of developmental processes, particularly in the formation of various tissues and organs. As such, the inhibition of HOXA3 by these compounds represents a strategic approach to modulating specific genetic pathways associated with embryonic morphogenesis and cellular differentiation.
The molecular mechanisms underlying HOXA3 inhibition involve the interference with key signaling pathways or transcriptional processes associated with the expression of the gene. These inhibitors often interact with specific molecular targets or components involved in the regulation of HOXA3, thereby disrupting the normal cellular processes guided by this gene. By selectively impeding the function of HOXA3, these inhibitors may influence the intricate cascade of events that govern cellular fate during embryonic development. The design and development of HOXA3 inhibitors stem from a deep understanding of the molecular biology of the HOXA gene family, aiming to provide researchers with valuable tools for investigating the intricacies of gene regulation and embryonic development
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib can hinder the degradation of proteins by the proteasome, potentially leading to reduced transcription factor activity and indirectly affecting the pathways in which HOXA3 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits the PI3K/Akt pathway, which can regulate various cellular processes. This inhibition could lead to altered cellular contexts that indirectly affect HOXA3's role. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 inhibits Wnt production, which can affect cell differentiation and development. As HOXA3 is involved in developmental processes, altering Wnt signaling can indirectly affect its function. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
By inhibiting the Hedgehog signaling pathway, cyclopamine can alter cell growth and patterning in development, potentially affecting HOXA3-related processes. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG490 can inhibit the JAK/STAT pathway, which is involved in various cellular processes, including development and differentiation that may intersect with HOXA3's roles. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, a kinase involved in numerous signaling pathways, including those related to development and differentiation which are also influenced by HOXA3. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which is part of the MAPK/ERK pathway. This pathway's inhibition can lead to changes in cell cycle and growth, possibly affecting HOXA3's developmental role. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 can inhibit TGF-β signaling, which is involved in cellular differentiation and proliferation, processes in which HOXA3 might also play a part. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT can inhibit γ-secretase, an enzyme necessary for Notch receptor activation. Notch signaling is involved in cell fate decisions, which can impact the biological context of HOXA3's action. | ||||||