HoxA11 Activators
HoxA11 activators are a specialized group of chemical compounds that aim to modulate the activity of the HoxA11 protein, which belongs to the Homeobox gene family. These genes are crucial transcription factors involved in the regulation of developmental processes and gene expression patterns. HoxA11 itself plays a significant role in embryonic development, particularly in the formation of the limbs, the axial skeleton, and the urogenital system.
The activators of HoxA11 can function either through direct or indirect mechanisms to enhance the protein's transcriptional activity. Direct activators would likely interact with HoxA11 at its DNA-binding domain or at other regulatory sites that are essential for its function. By binding to these sites, direct activators may alter the conformation of HoxA11, thus increasing its ability to bind DNA and regulate gene expression effectively. This could lead to the upregulation of downstream target genes that are under the control of HoxA11. Indirect activators, in contrast, may influence HoxA11 activity by altering the cellular environment or signaling pathways that impact the protein's expression, stability, or its ability to interact with co-factors and other components of the transcriptional machinery. Such indirect mechanisms could include the modulation of signaling pathways that control the transcription or translation of HoxA11, the inhibition of proteins that repress HoxA11's function, or the modification of epigenetic marks on the HoxA11 gene or its regulatory elements that affect its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a metabolite of Vitamin A and is known to regulate Hox gene expression. It enhances the activity of HoxA11 by binding to retinoic acid receptors, which then bind to retinoic acid response elements on the HoxA11 gene, leading to its activation and increased functional activity. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol, a form of estrogen, can enhance HoxA11 activity. It binds to estrogen receptors, which then bind to estrogen response elements on the HoxA11 gene, leading to its activation and increased functional activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a corticosteroid, has been shown to upregulate HoxA11. It binds to glucocorticoid receptors, which then bind to glucocorticoid response elements on the HoxA11 gene, leading to its activation and increased functional activity. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone, a hormone, can enhance HoxA11 activity. It binds to progesterone receptors, which then bind to progesterone response elements on the HoxA11 gene, leading to its activation and increased functional activity. | ||||||
L-Thyroxine, free acid | 51-48-9 | sc-207813 sc-207813A | 100 mg 500 mg | $35.00 $74.00 | 2 | |
Thyroxine, a thyroid hormone, can enhance HoxA11 activity. It binds to thyroid hormone receptors, which then bind to thyroid hormone response elements on the HoxA11 gene, leading to its activation and increased functional activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin has been shown to upregulate Hox genes. It binds to insulin receptors, which activate the PI3K/AKT pathway. This leads to the activation of downstream factors that bind to response elements on the HoxA11 gene, resulting in its activation and increased functional activity. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
Leptin, a hormone, can enhance HoxA11 activity. It binds to leptin receptors, which activate the JAK/STAT pathway. This leads to the activation of downstream factors that bind to response elements on the HoxA11 gene, resulting in its activation and increased functional activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, a hormone, can enhance HoxA11 activity. It binds to adrenergic receptors, which activate the cAMP pathway. This leads to the activation of downstream factors that bind to response elements on the HoxA11 gene, resulting in its activation and increased functional activity. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose, a simple sugar, can enhance HoxA11 activity. Increased glucose levels trigger the release of insulin, which, as mentioned earlier, can lead to the activation of HoxA11. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a histone deacetylase inhibitor that can enhance HoxA11 activity. It influences chromatin structure and gene expression, leading to an open chromatin conformation at the HoxA11 gene locus, which results in its activation and increased functional activity. | ||||||