hnRNP E1 Inhibitors
hnRNP E1 inhibitors belong to a distinct chemical class of molecules designed to modulate the activity of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1), a crucial protein in cellular RNA metabolism. hnRNP E1 is a multifunctional RNA-binding protein found predominantly in the nucleus of eukaryotic cells. It plays an essential role in RNA processing, including splicing, transport, and stability, by binding to specific RNA sequences and influencing their fate within the cell. These inhibitors are designed to interact with hnRNP E1, either directly or indirectly, and alter its function, leading to downstream effects on RNA processing events.
The molecular structure of hnRNP E1 inhibitors can vary widely, but they typically possess features that allow them to interfere with hnRNP E1's RNA-binding capacity or its interactions with other proteins. By disrupting these interactions, hnRNP E1 inhibitors can influence the fate of various RNA molecules within the cell, leading to changes in gene expression, alternative splicing patterns, or the stability of specific transcripts. Understanding the mechanisms by which hnRNP E1 inhibitors exert their effects is essential for unraveling the intricate web of RNA regulation within cells and may hold promise for future research in deciphering the broader biological consequences of hnRNP E1 modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This HDAC inhibitor can alter chromatin structure, potentially affecting the transcription of various genes, including PCBP1. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
As a DNA methylation inhibitor, it could lead to demethylation of the PCBP1 gene promoter, influencing hnRNP E1 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This mTOR inhibitor can affect protein synthesis in general, which might lead to reduced hnRNP E1 expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that could influence the degradation of hnRNP E1 or its precursors. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
A kinase inhibitor that might regulate the activity or stability of hnRNP E1. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
A splicing inhibitor that could potentially affect hnRNP E1 activity due to its role in RNA processing. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
An HSP90 inhibitor that could affect the stability and function of hnRNP E1. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
An RNA polymerase II inhibitor that could reduce the transcription of various genes, including PCBP1. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A compound known to inhibit various transcription factors and might influence PCBP1 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that could modulate cell signaling pathways involved in the regulation of PCBP1. | ||||||