HNF-4B Activators
Hepatocyte Nuclear Factor 4 Beta (HNF-4B) is a putative transcription factor that is presumably part of the HNF-4 family, which plays a pivotal role in the regulation of gene expression within various tissues, including the liver, kidney, and intestines. While the specific functions of HNF-4B may share similarities with its more extensively studied isoforms, such as HNF-4 alpha, it is important to recognize the unique regulatory pathways it may influence. The expression of HNF-4B is thought to be critical in the maintenance of normal cellular functions, influencing the transcriptional networks involved in metabolic processes and cellular differentiation. The precise mechanisms through which HNF-4B operates, including its DNA-binding specificity and interaction with co-regulators, remain areas of active investigation. Research into HNF-4B and its regulatory mechanisms is driven by the broader understanding that precise control of gene expression is essential for maintaining cellular homeostasis and responding to physiological stimuli.
A variety of endogenous chemical compounds serve as activators for nuclear receptor families and have the potential to induce the expression of proteins like HNF-4B. Fatty acids such as linoleic and oleic acid are natural ligands that may stimulate HNF-4B by binding to and activating certain nuclear receptors, which in turn could enhance the transcription of genes involved in lipid metabolism. Similarly, compounds like phytosterols and 25-hydroxycholesterol can interact with liver X receptors, potentially increasing the expression of HNF-4B and thereby influencing cholesterol homeostasis. Other molecules, such as retinoic acid and its derivative, 9-cis-retinoic acid, may also play a role in upregulating HNF-4B through their interactions with retinoid X receptors, which are known to form heterodimers with HNF-4. Additionally, synthetic compounds like fibrates (e.g., fenofibrate and bezafibrate) and thiazolidinediones (e.g., pioglitazone) are known to activate peroxisome proliferator-activated receptors, which could lead to increased HNF-4B expression, reflecting the interconnected nature of nuclear receptor signaling pathways. It is through the intricate dance of these activators with nuclear receptors that the expression of HNF-4B is potentially induced, thereby contributing to the regulation of genes that are essential for cellular metabolism and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can upregulate HNF-4B expression by binding to the retinoid X receptor (RXR), which can form heterodimers with HNF-4, altering the transcriptional control of genes related to metabolism. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $33.00 $63.00 $163.00 $275.00 | 4 | |
Linoleic acid may serve as a ligand for nuclear receptors that dimerize with HNF-4B, stimulating its transcriptional activity in fatty acid metabolism pathways. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate, by activating peroxisome proliferator-activated receptor alpha (PPARα), could promote the transcription of HNF-4B, given the cross-talk between PPARα and HNF-4 in hepatic lipid metabolism. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone may stimulate HNF-4B expression by binding to glucocorticoid receptors, which can initiate a cascade of transcriptional events influencing genes in glucose metabolism pathways. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, through activation of PPARγ, could upregulate HNF-4B, as PPARγ plays a key role in the transcriptional regulation of insulin-sensitizing genes, some of which may be HNF-4B targets. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
9-cis-Retinoic acid could induce HNF-4B by binding to RXRs, thereby enhancing the transcription of genes involved in lipid metabolism that are regulated by HNF-4B. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid may stimulate the expression of HNF-4B by serving as a natural ligand for nuclear receptors that partner with HNF-4B, promoting the transcription of genes involved in fatty acid biosynthesis. | ||||||
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $52.00 $89.00 $166.00 $465.00 | 8 | |
25-Hydroxycholesterol may induce HNF-4B expression via activation of LXRs, which are instrumental in maintaining cholesterol homeostasis and may engage in transcriptional regulation with HNF-4B. | ||||||
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $48.00 $121.00 $567.00 $998.00 $4480.00 | 11 | |
Cholic acid can stimulate HNF-4B expression through the farnesoid X receptor (FXR), which is involved in the transcriptional network governing bile acid synthesis and may include HNF-4B among its regulatory targets. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
WY 14643, as a PPARα agonist, may promote increased expression of HNF-4B due to the interplay between PPARα signaling and hepatic gene expression profiles, including those genes that HNF-4B may regulate. | ||||||