HNF-3γ Activators
The chemical class known as HNF-3γ Activators consists of various compounds that can either directly or indirectly enhance the activity of HNF-3γ, a transcription factor involved in critical cellular processes. These activators influence HNF-3γ-mediated functions by targeting specific biochemical and cellular pathways. For example, Retinoic Acid acts as a direct activator by binding to retinoic acid receptors (RARs) and regulating HNF-3γ transcriptional activity. Dexamethasone directly activates HNF-3γ expression by binding to glucocorticoid receptors and modulating transcription. Forskolin indirectly activates HNF-3γ through cAMP signaling pathways by activating adenylate cyclase, leading to increased cAMP levels. Lithium Chloride indirectly activates HNF-3γ by inhibiting GSK-3β, which stabilizes β-catenin and subsequently activates HNF-3γ transcription. 6-Bromoindirubin-3'-oxime also indirectly activates HNF-3γ by inhibiting GSK-3β and promoting β-catenin stabilization.
Additionally, ATRA (All-trans retinoic acid) directly activates HNF-3γ by binding to retinoic acid receptors (RARs) and enhancing its transcriptional activity. SB216763 indirectly activates HNF-3γ by inhibiting GSK-3β, leading to β-catenin accumulation and subsequent HNF-3γ activation. Resveratrol indirectly activates HNF-3γ through SIRT1 activation, which influences HNF-3γ expression and function. 3-Deazaneplanocin A (DZNep) indirectly activates HNF-3γ by inhibiting EZH2, resulting in altered histone methylation and HNF-3γ transcription. Butyrate indirectly activates HNF-3γ by inhibiting HDACs, leading to changes in chromatin structure and HNF-3γ transcription. A-769662 indirectly activates HNF-3γ by activating AMPK, which modulates cellular processes affecting HNF-3γ function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Acts as a direct activator by binding to retinoic acid receptors (RARs) and regulating HNF-3γ transcriptional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, leading to increased cAMP levels, which indirectly influence HNF-3γ through cAMP signaling pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Directly activates HNF-3γ expression by binding to glucocorticoid receptors and modulating transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Indirectly activates HNF-3γ through the inhibition of GSK-3β, leading to stabilization of β-catenin and subsequent HNF-3γ activation. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
Indirectly activates HNF-3γ by inhibiting GSK-3β and promoting β-catenin stabilization, which activates HNF-3γ transcription. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
Indirectly activates HNF-3γ by inhibiting GSK-3β, leading to β-catenin accumulation and subsequent HNF-3γ activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Indirectly activates HNF-3γ through SIRT1 activation, which influences HNF-3γ expression and function. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Indirectly activates HNF-3γ by inhibiting HDACs, leading to changes in chromatin structure and HNF-3γ transcription. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
Indirectly activates HNF-3γ by activating AMPK, which modulates cellular processes affecting HNF-3γ function. | ||||||