HIV-1 Tat-SF1 Inhibitors
The inhibitors listed above primarily target transcriptional regulation and HIV replication processes, which could indirectly influence HIV-1 Tat-SF1 activity. Given Tat-SF1's role in HIV transcription and replication, modulation of these processes is relevant for understanding its function and potential regulation. Flavopiridol and DRB, by inhibiting CDK9 and CDK7, can affect transcription elongation, potentially impacting Tat-SF1's function. Triptolide, targeting the Pol II complex, and BET bromodomain inhibitors (JQ1 and I-BET151) can modulate transcription, potentially influencing Tat-SF1 activity.
Curcumin and compounds like Prostratin and SAHA, which modulate HIV transcription and latency, could indirectly affect Tat-SF1's role in HIV replication. Disulfiram, by affecting latent HIV, and epigenetic modulators like Chaetocin and RG-108, can impact transcriptional regulation, potentially influencing Tat-SF1. Pladienolide B, targeting spliceosome, might indirectly affect processes relevant to Tat-SF1 in HIV replication.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
Flavopiridol, a CDK9 inhibitor, can impede transcription elongation by Pol II, potentially affecting Tat-SF1 mediated processes in HIV replication. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits CDK9 and CDK7, which are essential for Pol II function, potentially impacting Tat-SF1's role in transcription elongation. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits the XPB subunit of TFIIH in the Pol II complex, potentially affecting transcription processes involving Tat-SF1. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1, a BET bromodomain inhibitor, can modulate transcription, potentially influencing Tat-SF1's function in HIV replication. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is another BET bromodomain inhibitor that can affect transcription regulation, potentially impacting Tat-SF1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to inhibit HIV-1 Tat-mediated transactivation, potentially affecting Tat-SF1's role in this process. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $138.00 $530.00 | 24 | |
Prostratin affects HIV transcription by activating latent viral reservoirs, potentially influencing Tat-SF1's function. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can reactivate latent HIV, potentially influencing Tat-SF1's role in viral replication. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin, a histone methyltransferase inhibitor, might impact transcription regulation, affecting Tat-SF1's function. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Pladienolide B targets the spliceosome, potentially influencing pre-mRNA processing relevant to Tat-SF1. | ||||||