Anti-HIV-1 Tat-SF1 Antibody (C-4) is a mouse monoclonal IgG2b κ HIV-1 Tat-SF1 antibody, cited in 1 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 1-23 at the N-terminus of HIV-1 Tat-SF1 of mouse origin
Anti-HIV-1 Tat-SF1 Antibody (C-4) is recommended for detection of HIV-1 Tat-SF1 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-HIV-1 Tat-SF1 Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of HIV-1 Tat-SF1 (C-4): sc-514351.
m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HIV-1 Tat-SF1 Antibody (C-4) for WB applications. These reagents are now offered in bundles with HIV-1 Tat-SF1 Antibody (C-4) (see ordering information below).
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HIV-1 Tat-SF1 Antibody (C-4) is a high quality monoclonal HIV-1 Tat-SF1 antibody (also designated HIV-1 Tat-SF1 antibody) suitable for the detection of the HIV-1 Tat-SF1 protein of mouse, rat and human origin. HIV-1 Tat-SF1 Antibody (C-4) is available as both the non-conjugated anti-HIV-1 Tat-SF1 antibody form, as well as multiple conjugated forms of anti-HIV-1 Tat-SF1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. HIV-1 Tat-SF1 (HIV-1 Tat-specific factor 1) is a phosphoprotein that plays a role in the process of transcriptional elongation. It is ubiquitously expressed and localizes to the nucleus. HIV-1 Tat-SF1 interacts with Tat, P-TEFb, TFIIF RAP 30, CA150, Spt5, Pol II and U snRNPs. It is structurally similar to CUS2 in yeast. HIV-1 Tat-SF1 contains an acidic C-terminal motif and two RNA recognition motif (RRM) domains that mediate its interaction with U snRNPs. HIV-1 Tat-SF1 forms a complex with U snRNP, thereby coupling transcription and splicing. HIV-1 Tat-SF1 expression is upregulated by the HIV-1 proteins Nef and gp120. It acts as a cofactor for the Tat-enhanced transcription of HIV-1 and is required, along with SPT5, for the activation of Tat. Overexpression of Tat-SF1 and SPT5 stimulates the transcriptional activity of Tat.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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