HIT-40 Inhibitors
HIT-40 inhibitors encompass a diverse range of compounds that affect various cellular signaling pathways, leading to the inhibition of HIT-40 activity. LY294002 and Wortmannin are two compounds that target the PI3K/Akt pathway, which is essential for the phosphorylation and activation of HIT-40.
By inhibiting PI3K, these compounds prevent the activation of Akt and subsequent activation of HIT-40. Similarly, the mTOR inhibitor Rapamycin suppresses the mTOR pathway, which is vital for protein synthesis and downstream signaling events that activate HIT-40. PD98059 and SB203580 are inhibitors of the MAPK pathway, through MEK and p38 MAPK respectively. HIT-40's regulatory mechanisms are influenced by the MAPK pathway, and the inhibition of this pathway results in decreased activation of HIT-40 due to reduced phosphorylation events.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A phosphoinositide 3-kinase (PI3K) inhibitor. HIT-40 is downstream of the PI3K/Akt pathway; inhibition of PI3K by LY294002 prevents the activation of Akt, leading to a reduction in HIT-40 activity because HIT-40 requires Akt-mediated phosphorylation for full activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor. Since HIT-40 is a downstream effector in the mTOR pathway, inhibition of mTOR by rapamycin can suppress protein synthesis and downstream signaling events that are essential for HIT-40 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor. HIT-40 activity is modulated by stress-activated protein kinases; SB203580 inhibits p38 MAPK, which is involved in the cellular stress response, leading to the suppression of HIT-40 activity indirectly due to the reliance of HIT-40 on stress-induced signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor that blocks the MAPK/ERK pathway. HIT-40 is regulated by the ERK pathway, and inhibition of MEK by PD98059 downregulates ERK activity, consequently decreasing HIT-40 activity due to lower phosphorylation levels. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A potent PI3K inhibitor. Similar to LY294002, wortmannin blocks PI3K activity, preventing Akt activation and subsequent HIT-40 activity as PI3K/Akt signaling is crucial for the phosphorylation and activation of HIT-40. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK). HIT-40 is indirectly influenced by the JNK pathway, which is involved in stress responses and apoptosis. Inhibition of JNK by SP600125 can lead to reduced HIT-40 activity as part of the cellular response to stress. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
A protein kinase C (PKC) inhibitor. HIT-40 operates downstream of PKC, and inhibition of PKC by Gö6976 decreases the activation of pathways that facilitate HIT-40 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A Rho-associated protein kinase (ROCK) inhibitor. As HIT-40 is modulated by actin cytoskeleton dynamics, inhibition of ROCK by Y-27632 affects cell shape and motility, which can lead to decreased HIT-40 activity due to its reliance on cytoskeletal integrity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A calcium chelator that reduces intracellular calcium levels. Given that HIT-40 is activated by calcium-dependent pathways, the use of BAPTA-AM to chelate calcium can reduce HIT-40 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). By inhibiting SERCA, thapsigargin raises cytosolic calcium levels, which paradoxically can inhibit calcium signaling pathways and thereby decrease HIT-40 activity, as sustained high calcium levels can desensitize calcium-dependent proteins. | ||||||