Histone Modification
Items 31 to 40 of 101 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a potent inhibitor of histone acetyltransferases, specifically targeting the p300/CBP family. By disrupting the acetylation of histones, C646 alters chromatin dynamics, leading to a more compact structure that can hinder transcriptional activation. Its unique binding affinity allows for selective modulation of histone marks, influencing gene expression patterns. The compound's kinetic profile reveals rapid engagement with target enzymes, underscoring its potential for precise epigenetic regulation. | ||||||
Butyrolactone 3 | 778649-18-6 | sc-358657 sc-358657A sc-358657B | 5 mg 50 mg 100 mg | $219.00 $1467.00 $2819.00 | 3 | |
Butyrolactone 3 serves as a selective modulator of histone modifications, particularly influencing histone methylation processes. Its unique structure facilitates specific interactions with methyltransferases, promoting alterations in chromatin architecture. This compound exhibits distinct reaction kinetics, allowing for nuanced regulation of gene expression by stabilizing or destabilizing histone-DNA interactions. The resulting epigenetic changes can significantly impact cellular functions and developmental pathways. | ||||||
Suberoyl bis-hydroxamic Acid | 38937-66-5 | sc-200887 sc-200887A | 100 mg 500 mg | $50.00 $104.00 | ||
Suberoyl bis-hydroxamic Acid is a potent inhibitor of histone deacetylases, engaging in specific interactions with the active sites of these enzymes. Its dual hydroxamic acid groups enhance binding affinity, leading to significant alterations in histone acetylation levels. This compound exhibits unique kinetics, allowing for precise modulation of chromatin dynamics, which can influence transcriptional regulation and cellular signaling pathways, thereby affecting gene expression profiles. | ||||||
Cdk5 substrate | sc-3066 | 500 µg | $91.00 | 2 | ||
Cdk5 Substrate plays a crucial role in histone modification by serving as a target for cyclin-dependent kinase 5 (Cdk5) phosphorylation. This substrate undergoes specific phosphorylation events that alter its interaction with chromatin, influencing histone dynamics. The phosphorylation enhances the recruitment of chromatin remodeling complexes, thereby modulating gene expression. Its unique reaction kinetics allow for rapid and reversible modifications, impacting cellular processes such as differentiation and response to stress. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine is a potent inhibitor of DNA methylation, influencing histone modification through its incorporation into DNA. This incorporation disrupts the binding of methyltransferases, leading to altered chromatin structure. The compound's unique ability to induce hypomethylation results in the activation of silenced genes, facilitating distinct epigenetic reprogramming. Its interactions with histone deacetylases further enhance chromatin accessibility, promoting dynamic changes in gene expression profiles. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin is a selective inhibitor of histone methyltransferases, particularly targeting the SETD2 enzyme. By binding to the active site, it disrupts the methylation of histone H3 at lysine 36, leading to a cascade of epigenetic modifications. This alteration in histone marks results in a reconfiguration of chromatin architecture, enhancing transcriptional activity of specific genes. Its unique mechanism of action highlights the intricate balance of histone modifications in regulating gene expression. | ||||||
ITSA1 | 200626-61-5 | sc-200894B sc-200894 sc-200894A | 10 mg 25 mg 100 mg | $67.00 $109.00 $317.00 | 4 | |
ITSA1 is a potent modulator of histone acetylation, specifically influencing the activity of histone acetyltransferases. By interacting with key residues in the enzyme's active site, it promotes the transfer of acetyl groups to lysine residues on histones, resulting in a more relaxed chromatin structure. This alteration facilitates increased accessibility for transcription factors, thereby fine-tuning gene expression dynamics. Its distinct pathway underscores the complexity of epigenetic regulation. | ||||||
CTPB | 586976-24-1 | sc-202558 sc-202558A | 1 mg 5 mg | $59.00 $165.00 | 4 | |
CTPB serves as a significant player in histone modification by acting as a selective inhibitor of histone deacetylases (HDACs). Its unique structure allows for specific binding to the catalytic sites of HDACs, disrupting their activity and leading to an accumulation of acetylated histones. This accumulation alters chromatin conformation, enhancing transcriptional activation. The kinetic profile of CTPB reveals a rapid onset of action, highlighting its role in modulating epigenetic landscapes. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX01294 hydrochloride is a potent inhibitor of histone methyltransferases, specifically targeting the enzyme G9a. Its unique binding affinity allows it to selectively disrupt the methylation of histone H3 at lysine 9, leading to altered chromatin dynamics. This modification promotes a more open chromatin structure, facilitating gene expression. The compound exhibits distinct reaction kinetics, with a notable half-life that supports sustained epigenetic modulation, influencing cellular processes. | ||||||
HDAC6 Inhibitor Inhibitor | 1045792-66-2 | sc-223877 sc-223877A | 500 µg 1 mg | $63.00 $88.00 | 5 | |
HDAC6 Inhibitor is a selective modulator of histone deacetylation, primarily interacting with the HDAC6 enzyme. By disrupting the deacetylation of lysine residues on histones, it enhances acetylation levels, leading to a more relaxed chromatin configuration. This alteration in histone modification can influence various cellular signaling pathways. The inhibitor demonstrates unique binding characteristics, allowing for specific interactions that impact gene regulation and chromatin accessibility. | ||||||