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ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. TSA (Trichostatin A) is an inhibitor of histone deacetylase. ITSA1 was found to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation.
1. Haggarty, S.J., et al. 2003. Chem. Biol. 10: 1267-1279. PMID: 14700634
2. Koeller, K.M., et al. 2003. Chem. Biol. 10: 397-410. PMID: 12770822
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