Suberoyl bis-hydroxamic Acid, an HDAC (histone deacetylase) inhibitor, inhibits HDAC1 (ID50 = 0.25 μM) and HDAC3 (ID50 = 0.3 μM). Suberoyl bis-hydroxamic Acid has been shown to induce differentiation of certain murine cells via blocking of HEXIM1 (hexamethylene bisacetamide) activity. Other experiments have shown Suberoyl bis-hydroxamic Acid to induce apoptosis in proliferative cells via induction of P21, P53, PUMA, and Bax gene expression. Additionally, the compound has been noted to activate Notch 1 signaling, which is associated with antiproliferative and apoptotic effects in certain medullary cells. Additional proteins induced by Suberoyl bis-hydroxamic Acid include caspase-3, poly ADP-ribose polymerase, Bcl-X(L), and Bad whose effects range from cellular growth, senescence and apoptosis.
1. Preston, C.M. and McFarlane, M. 1998. Virology. 249: 418-426. PMID: 9791032 2. Zhuang, Z.G., et al. 2008. Acta Pharmacol. Sin. 29: 1459-1466. PMID: 19026165 3. Ning, L., et al. 2008. Oncologist. 13: 98-104. PMID: 18305053 4. Flis, S., et al. 2009. Biochem. Biophys. Res. Commun. 387: 336-341. PMID: 19596269
Soluble in DMSO (~1.3 mg/ml), DMF (~0.1 mg/ml), and a 1:10 solution of DMSO:PBS(pH7.2) (~0.1 mg/ml).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Yang X; et alYang X; et al. (PubMed ID: 25501628) determined that Suberoyl bis-hydroxamic Acid has cytotoxic effects on MCF-7 due to down-regulation of Bcl 2. -SCBT Publication Review
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