Suberoyl bis-hydroxamic Acid (CAS 38937-66-5)

Suberoyl bis-hydroxamic acid (SBHA) is an organic compound with potent properties as a histone deacetylase (HDAC) inhibitor, primarily utilized in molecular biology research to explore gene expression and chromatin dynamics. SBHA functions by binding to the zinc ions within the active site of HDACs, thus inhibiting their deacetylase activity which is critical for chromatin remodeling and subsequent gene transcription regulation. The inhibition of HDACs leads to an increased acetylation of histone proteins, resulting in a more open chromatin structure and promoting transcriptional activation of previously silenced genes. This mechanism is vital for understanding the epigenetic regulation of gene expression and has significant implications in the study of developmental biology and oncogenesis. Researchers leverage SBHA to dissect the roles of specific genes and their associated pathways in cellular differentiation, apoptosis, and cellular response to stress. Its application extends to studying the modulation of inflammatory responses and immune signaling pathways, showcasing its versatility and importance in elucidating complex biological processes. As such, SBHA serves as a crucial tool in the arsenal of researchers aiming to unravel the complex web of epigenetic regulation at the molecular level.