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HDAC6 Inhibitor is a selective and potent inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with HDAC1 (IC50 = 271 nM), HDAC2 (IC50 = 252 nM), HDAC3 (IC50 = 0.42 nM), HDAC8 (IC50 = 6851 nM), and HDAC10 (IC50 = 90.7 nM). HDAC6 Inhibitor also prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). HDAC6 Inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroamic acid (sc-220139).
1. Kozikowski, Alan P., et al., 2008. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. Journal of medicinal chemistry. 51(15): 4370-3. PMID: 18642892
See how others have used HDAC6 Inhibitor. Click on the entry to view the PubMed entry .
PMID: # 28767685 Takano, K. et al. 2017. PLoS ONE. 12: e0182291.
PMID: # 27363897 Janjanam, J. et al. 2016. Scientific reports. 6: 28687.
PMID: # 25342559 Yang, Y. et al. 2014. Cell Res. 24: 1342-53.
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