Histone H1 Inhibitors
Histone H1 inhibitors represent a distinctive and specialized class of chemical entities with a remarkable capacity to intricately modulate the functions of histone H1 proteins. Embedded within the intricate three-dimensional matrix of chromatin, which constitutes the amalgamation of DNA and diverse proteins within the cellular nucleus, histone H1 assumes a strategic positioning. Unlike the core histones, namely H2A, H2B, H3, and H4, which intimately embrace the DNA helix, histone H1 is strategically positioned at the entry and exit points of the nucleosomal DNA. This strategic placement empowers histone H1 to act as a master regulator, orchestrating the higher-order architecture of chromatin and delicately fine-tuning the accessibility of genes for transcription.
The finesse of histone H1 inhibitors lies in their precision-engineered molecular structures, designed to selectively intervene in the intricate interplay between histone H1 and DNA. By doing so, these inhibitors have the ability to induce structural alterations in chromatin, thereby setting the stage for a cascade of molecular events that ripple across the genomic landscape.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quinacrine, Dihydrochloride | 69-05-6 | sc-204222 sc-204222B sc-204222A sc-204222C sc-204222D | 100 mg 1 g 5 g 200 g 300 g | $45.00 $56.00 $85.00 $3193.00 $4726.00 | 4 | |
Originally developed as an antimalarial agent, quinacrine has been investigated for its potential to inhibit histone H1 and affect chromatin structure. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
A compound used in studies of malaria and autoimmune diseases. They have been studied for their effects on chromatin and histone H1 inhibition. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
This compound is a class I selective histone deacetylase (HDAC) inhibitor, which indirectly affects histone H1 function by altering chromatin structure through histone acetylation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Another HDAC inhibitor that can indirectly impact histone H1 through histone acetylation and chromatin remodeling. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
An HDAC inhibitor that can modify histone acetylation and potentially influence histone H1 dynamics. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
While primarily known as a histone methyltransferase (HMT) inhibitor, it can affect histone H1 dynamics indirectly by influencing other chromatin modifications. | ||||||
Salermide | 1105698-15-4 | sc-224276 sc-224276A | 5 mg 10 mg | $70.00 $105.00 | 3 | |
This compound inhibits sirtuin deacetylases, which can influence histone H1 acetylation and chromatin structure. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A natural compound found in turmeric, curcumin has been investigated for its potential to modulate histone H1 and chromatin organization. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $108.00 $336.00 | 9 | |
An HDAC inhibitor that can influence histone acetylation and, consequently, histone H1 interactions with chromatin. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is also an HDAC inhibitor that can impact histone H1 dynamics. | ||||||