Histone cluster 2 H3C1 Inhibitors
Chemical inhibitors of Histone cluster 2 H3C1 function by disrupting the enzymatic activity of histone deacetylases (HDACs), which are responsible for the removal of acetyl groups from the lysine residues on histone proteins. These acetyl groups play a key role in the regulation of chromatin structure and gene expression. When HDACs are inhibited, acetyl groups remain attached to Histone cluster 2 H3C1, leading to a relaxed chromatin state that is associated with increased gene transcription. Trichostatin A, for instance, is known to bind directly to HDACs, thereby preventing the deacetylation of Histone cluster 2 H3C1. This inhibition promotes a more open chromatin conformation, preventing the tight winding of DNA around the histone, which in turn facilitates transcriptional activation.
Similarly, compounds like Vorinostat, Romidepsin, and Belinostat increase the levels of acetylation on Histone cluster 2 H3C1, leading to changes in gene expression. Vorinostat, specifically, is a broad-spectrum HDAC inhibitor that causes hyperacetylation of histones, including Histone cluster 2 H3C1. This hyperacetylated state disrupts the normal histone-DNA interactions, affecting the accessibility of transcriptional machinery to DNA. Other compounds such as Panobinostat and Mocetinostat also act on HDACs, but can target specific isoforms, modulating acetylation in a more targeted manner, which likewise impacts the Histone cluster 2 H3C1 function. Additional HDAC inhibitors like Entinostat, Givinostat, and Chidamide also increase acetylation of Histone cluster 2 H3C1, consequently altering chromatin structure and function. Short-chain fatty acids like Sodium Butyrate, as well as other molecules like Valproic Acid, also serve as HDAC inhibitors, increasing histone acetylation and influencing the chromatin state mediated by Histone cluster 2 H3C1. These chemical inhibitors collectively maintain Histone cluster 2 H3C1 in an acetylated state, thus regulating chromatin architecture and affecting the transcriptional activity associated with this histone.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase, an enzyme that removes acetyl groups from the lysine residues in histones, including Histone cluster 2 H3C1. This inhibition prevents the deacetylation of Histone cluster 2 H3C1, which is necessary for the tight winding of DNA around histones, leading to a more relaxed chromatin structure and reduced accessibility of the DNA for transcription. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that targets specific isoforms of the enzyme. By inhibiting these isoforms, mocetinostat can increase the acetylation levels of histones, such as Histone cluster 2 H3C1, disrupting the normal chromatin structure and function. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat is another histone deacetylase inhibitor that leads to the accumulation of acetylated histones, including Histone cluster 2 H3C1. This accumulation alters gene expression patterns and can inhibit the functional role of Histone cluster 2 H3C1 in maintaining chromatin structure and regulating gene transcription. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent histone deacetylase inhibitor that broadly affects the acetylation status of histones including Histone cluster 2 H3C1. By doing so, it disrupts the chromatin compaction essential for the proper transcriptional repression and activation, thereby functionally inhibiting Histone cluster 2 H3C1. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, also known as SAHA, inhibits histone deacetylases, which in turn leads to an increase of acetylated histones, such as Histone cluster 2 H3C1. The hyperacetylated state prevents the histones from tightly binding DNA, affecting chromatin structure and function, and thereby inhibiting the normal function of Histone cluster 2 H3C1. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin functions as a histone deacetylase inhibitor, preventing deacetylation and maintaining a hyperacetylated state of histones, including Histone cluster 2 H3C1. This hyperacetylated state disrupts chromatin architecture and affects the transcription of genes regulated by Histone cluster 2 H3C1. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat is a histone deacetylase inhibitor that increases the acetylation levels of histones such as Histone cluster 2 H3C1. The result is an open chromatin structure that alters gene expression and inhibits the function of Histone cluster 2 H3C1 in the regulation of chromatin dynamics and transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, while known as an anticonvulsant, also acts as a histone deacetylase inhibitor. It can induce hyperacetylation of Histone cluster 2 H3C1, leading to a relaxed chromatin structure. This relaxation can functionally inhibit the role of Histone cluster 2 H3C1 in transcriptional repression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate is a short-chain fatty acid that acts as a histone deacetylase inhibitor. By inhibiting deacetylation, it promotes a hyperacetylated state of histones, including Histone cluster 2 H3C1, altering chromatin structure and function, thereby inhibiting Histone cluster 2 H3C1's role in gene regulation. | ||||||
ITF2357 | 732302-99-7 | sc-364513 sc-364513A | 5 mg 50 mg | $340.00 $1950.00 | ||
Givinostat is a histone deacetylase inhibitor that can increase the acetylation of histones, such as Histone cluster 2 H3C1. This increased acetylation disrupts the normal chromatin compaction, influencing gene expression and inhibiting the functional capabilities of Histone cluster 2 H3C1. | ||||||