Histone cluster 2 H2AB Inhibitors
The term Histone cluster 2 H2AB inhibitors refers to a specialized chemical class designed to selectively target and modulate the activity of histones within the cluster 2 H2AB group. Histones are fundamental proteins involved in the structural organization of DNA within the cell nucleus, forming the core components of nucleosomes. Histone cluster 2 H2AB represents a specific subgroup within the histone family, consisting of variants H2A and H2B, which play integral roles in regulating chromatin structure and gene expression.
The inhibitors developed for Histone cluster 2 H2AB are intricately designed to interact with the unique structural features of these histones, aiming to disrupt their normal interactions within the chromatin environment. By selectively inhibiting the functions of H2A and H2B within this histone cluster, researchers aim to explore the nuanced roles of these histone variants in various cellular contexts. Understanding the regulation and dynamics of histones, especially within specific clusters like Histone cluster 2 H2AB, contributes to the broader knowledge of epigenetic mechanisms and their impact on gene expression and cellular processes. The study of Histone cluster 2 H2AB inhibitors represents an essential avenue for advancing our comprehension of chromatin biology and the intricate molecular mechanisms governing gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that may increase histone acetylation, potentially disrupting the normal expression patterns of histone genes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine can lead to reduced DNA methylation, indirectly affecting histone modification and expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, which could result in hyperacetylation of histones and altered gene expression, including that of histones. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, may modify chromatin structure and affect the expression of a variety of genes, including histones. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid serves as a histone deacetylase inhibitor, potentially altering histone expression through changes in chromatin structure and function. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
Garcinol may inhibit histone acetyltransferases, which could lead to changes in the acetylation status of histones and thus their expression. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid has been shown to inhibit histone acetyltransferase activity, potentially affecting histone expression and chromatin structure. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to DNA and may interfere with transcription factor binding, potentially downregulating histone gene transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to affect various signaling pathways and may have an impact on histone modification enzymes, altering histone expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This compound can modulate enzyme activities related to DNA methylation and histone acetylation, potentially influencing histone expression. | ||||||