Histone cluster 1 H4M Inhibitors
Histone cluster 1 H4M inhibitors constitute a specialized class of chemical compounds meticulously designed to modulate the activity of histone cluster 1 H4M proteins. H4M, also known as H4 histone family member M, is part of the histone family of proteins found in humans and other organisms. Histones are fundamental components of chromatin, the complex structure that packages and organizes DNA in the cell nucleus. Chromatin plays a central role in regulating gene expression, DNA replication, and genome stability. H4M, as a subtype of histone H4, contributes to the dynamic organization of chromatin and the orchestration of various cellular processes.
Typically, H4M inhibitors consist of small molecules or chemical compounds that are precisely engineered to bind to H4M proteins, targeting either their active sites or allosteric sites. This interaction can lead to the modulation of H4M's behavior, potentially impacting its role in chromatin structure, gene expression, and DNA packaging. Researchers in the fields of molecular biology and pharmacology are dedicated to unraveling the molecular mechanisms and functions of histone cluster 1 H4M proteins within the context of chromatin dynamics, aiming to gain insights into the intricate processes that govern epigenetic regulation and genomic stability. The development of H4M inhibitors represents an ongoing and dynamic area of research, contributing significantly to our understanding of chromatin biology and its crucial role in gene expression and various cellular processes.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A nucleoside analog of cytidine that can be incorporated into DNA and RNA, leading to the inhibition of DNA methyltransferase and potentially affecting gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-azacytidine, this compound is a deoxycytidine analog that inhibits DNA methyltransferase, affecting DNA methylation and gene expression. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
A cytidine analog that traps DNA methyltransferases, leading to passive demethylation of DNA and potentially affecting gene transcription. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor that can prevent DNA methylation and potentially influence gene expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
A sesquiterpene lactone that may inhibit NF-κB, a transcription factor that can regulate histone gene expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can lead to altered protein synthesis and potentially affect the expression of various genes, including those for histones. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A phosphodiesterase inhibitor that raises cAMP levels, potentially affecting transcription factor activity and gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide that has been shown to inhibit the transcription of various genes, potentially affecting histone expression. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
A diazepin-quinazolinamine derivative that inhibits G9a and GLP histone lysine methyltransferases, potentially influencing gene expression. | ||||||
I-CBP112 | 1640282-31-0 | sc-507494 | 25 mg | $400.00 | ||
A small molecule that can inhibit the acetyltransferase activity of CBP/p300, which could potentially affect transcription and histone expression. | ||||||