Date published: 2026-3-31

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Histone cluster 1 H3F Inhibitors

Histone cluster 1 H3F Inhibitors belong to a specialized category of chemical compounds designed to selectively impede the activity of histone cluster 1, with a specific emphasis on the H3F subtype. Histones, fundamental in the organization of DNA within the nucleus, form nucleosomes that serve as the structural foundation for chromatin. The H3F designation refers to a variant of histone H3, one of the core histones essential for nucleosome assembly. As a specific variant within histone cluster 1, H3F becomes a focus of interest for researchers aiming to unravel the intricacies of chromatin dynamics and gene regulation.

The development of Histone cluster 1 H3F Inhibitors necessitates a thorough understanding of the structural characteristics of histone H3F and its specific role within chromatin organization. These inhibitors are meticulously crafted for specificity, aiming to selectively bind to key regions of Histone cluster 1 H3F and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H3F, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Panobinostat

404950-80-7sc-208148
10 mg
$200.00
9
(1)

Panobinostat is a histone deacetylase inhibitor, influencing chromatin structure and potentially affecting the acetylation status of histones, including H3F.

JIB 04

199596-05-9sc-397040
20 mg
$177.00
(0)

JIB-04 inhibits Jumonji histone demethylases, potentially impacting histone demethylation and the transcriptional regulation of genes, including H3F.

ACY-1215

1316214-52-4sc-507455
25 mg
$110.00
(0)

Rocilinostat is a histone deacetylase inhibitor, impacting chromatin structure and potentially affecting the acetylation status of histones, including H3F.

UNC0638

1255580-76-7sc-397012
10 mg
$315.00
(0)

UNC0638 inhibits G9a, a histone methyltransferase, potentially influencing the methylation status of histones and the expression of genes, including H3F.

GSK-J4

1373423-53-0sc-507551
100 mg
$1275.00
(0)

GSK-J4 inhibits lysine demethylase, potentially influencing histone demethylation and the transcriptional regulation of genes, including H3F.

EPZ6438

1403254-99-8sc-507456
1 mg
$66.00
(0)

EPZ-6438 targets EZH2, a histone methyltransferase, potentially impacting the methylation of histones and the expression of genes like H3F.

(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide

202590-98-5sc-501130
2.5 mg
$330.00
(0)

OTX015 is a bromodomain and extraterminal (BET) protein inhibitor, disrupting interactions between BET proteins and acetylated histones, potentially influencing gene expression.

GSK126

1346574-57-9sc-490133
sc-490133A
sc-490133B
1 mg
5 mg
10 mg
$92.00
$243.00
$306.00
(0)

GSK343 inhibits EZH2, potentially influencing histone methylation patterns and the transcriptional regulation of genes, including H3F.

C646

328968-36-1sc-364452
sc-364452A
10 mg
50 mg
$265.00
$944.00
5
(1)

C646 is a selective inhibitor of histone acetyltransferase, modulating the acetylation of histones and influencing the expression of associated genes, including H3F.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$218.00
$322.00
$426.00
7
(1)

Decitabine is a DNA methyltransferase inhibitor, potentially influencing DNA methylation patterns and the expression of genes, including H3F.