Histone cluster 1 H2AF Inhibitors
Histone cluster 1 H2AF inhibitors comprise a specific class of chemical compounds meticulously designed to modulate the activity of histone cluster 1 H2AF proteins. H2AF proteins, also known as H2A histone family member F, are a group of histone proteins found in humans and various organisms. Histones are essential proteins involved in chromatin structure and regulation of gene expression. They function by packaging DNA into a compact and organized structure, facilitating the regulation of transcription and other DNA-related processes. H2AF proteins are a specific subset of histones that play a role in the dynamic and intricate process of chromatin remodeling.
Typically, histone cluster 1 H2AF inhibitors consist of small molecules or chemical compounds that are specifically engineered to bind to H2AF proteins, targeting either their active sites or allosteric sites. This interaction can lead to the modulation of H2AF proteins' behavior, potentially affecting their roles in chromatin organization, gene regulation, and DNA packaging. Researchers are dedicated to unraveling the molecular mechanisms and functions of histone cluster 1 H2AF proteins within the context of chromatin dynamics and gene expression, aiming to gain insights into the complex processes that govern epigenetic regulation and genomic stability. The development of histone cluster 1 H2AF inhibitors represents an ongoing and dynamic area of research within the fields of molecular biology and pharmacology, contributing significantly to our understanding of chromatin biology and its impact on gene expression and cellular processes.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
A DNA polymerase inhibitor that can halt DNA replication and indirectly affect histone expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
A topoisomerase I inhibitor that induces DNA damage and can alter DNA replication. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
A topoisomerase II inhibitor that causes DNA strand breaks and can disrupt replication and chromatin assembly. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Induces replication stress by inhibiting ribonucleotide reductase, potentially affecting DNA synthesis and histone expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interferes with DNA-dependent RNA synthesis and could indirectly inhibit histone gene transcription. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
A CDK inhibitor that can arrest cell cycle progression and may reduce histone gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A compound shown to inhibit RNA polymerase II-mediated transcription, potentially affecting histone gene expression. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
A DNA intercalator and topoisomerase II inhibitor that can disrupt DNA replication and transcription. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
Incorporates into DNA and affects DNA and RNA synthesis, which could impact histone expression. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog that inhibits DNA synthesis, potentially affecting the expression of histones. | ||||||