Histone cluster 1 H1B Activators
Histone cluster 1 H1B activators are a specialized group of chemicals that target and modulate the activity of Histone cluster 1 H1B, a protein that is part of the H1 family of histone proteins. Histone H1B plays a critical role in the condensation of chromatin structure and the regulation of gene expression by acting as a linker histone; it binds to the nucleosome at the entry and exit sites of DNA, helping to stabilize the higher-order structure of chromatin.
Chemicals in this class can activate Histone H1B either directly or indirectly. Direct activators would typically bind to Histone H1B itself, potentially influencing its interaction with DNA and nucleosomes. This interaction could lead to conformational changes in the chromatin structure, making it either more or less accessible for transcription, depending on the nature of the binding and the subsequent chromatin remodeling. Such direct interaction could also affect the post-translational modifications of Histone H1B, which are known to play a crucial role in the regulation of its function. Indirect activators, on the other hand, would not bind to Histone H1B directly but would instead alter its activity through other pathways. This could include influencing the expression levels of Histone H1B by acting on the regulatory elements of its gene, or by modulating the activity of enzymes responsible for its post-translational modifications, such as kinases, phosphatases, acetyltransferases, or deacetylases. These modifications can have profound effects on Histone H1B's role in chromatin remodeling and gene expression regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase (HDAC) inhibitor. Its inhibition of HDAC leads to an increase in the acetylation of histones, including Histone cluster 1 H1B, resulting in relaxed chromatin structure and enhanced functional activity of the histone. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor. By inhibiting HDAC activity, it causes increased histone acetylation, thereby enhancing the functional activity of Histone cluster 1 H1B due to a more relaxed chromatin conformation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is an HDAC inhibitor. Inhibition of HDAC leads to increased histone acetylation and relaxed chromatin structure which enhances the functional activity of Histone cluster 1 H1B. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is an HDAC inhibitor. It enhances the functional activity of Histone cluster 1 H1B by increasing histone acetylation, leading to a relaxed chromatin structure. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is an HDAC inhibitor. It enhances the functional activity of Histone cluster 1 H1B by increasing histone acetylation and relaxing chromatin structure. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is an HDAC inhibitor. It has a direct impact on Histone cluster 1 H1B by increasing histone acetylation and enhancing the functional activity through a relaxed chromatin structure. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is a Sirtuin inhibitor that prevents deacetylation of histones, including Histone cluster 1 H1B, thereby maintaining a relaxed chromatin structure and enhancing the functional activity of the histone. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is an HDAC inhibitor. By inhibiting HDAC, it increases the acetylation of histones, enhancing the functional activity of Histone cluster 1 H1B by maintaining a relaxed chromatin structure. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is an HDAC inhibitor. It increases the acetylation of histones, including Histone cluster 1 H1B, leading to enhanced functional activity due to a more relaxed chromatin conformation. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat is an HDAC inhibitor. It enhances the functional activity of Histone cluster 1 H1B by increasing histone acetylation and relaxing chromatin structure. | ||||||