Date published: 2026-4-1

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HIGD1C Inhibitors

HIGD1C inhibitors represent a specific class of chemical compounds that have been meticulously designed to modulate the activity of the HIGD1C protein. HIGD1C, also known as Hypoxia Inducible Domain Family Member 1C, is a protein found in humans and is a member of the Hypoxia Inducible Gene Domain (HIGD) family. These proteins are known for their involvement in cellular responses to low oxygen levels, a condition known as hypoxia. Hypoxia can occur in various physiological and pathological contexts, and the cellular response to hypoxia is critical for cell survival and adaptation to low oxygen environments. HIGD1C, in particular, plays a role in regulating mitochondrial function and dynamics under hypoxic conditions, which is essential for cellular energy production and adaptation to low oxygen stress.

HIGD1C inhibitors typically consist of small molecules or chemical compounds that are specifically designed to bind to HIGD1C, targeting either its active site or allosteric sites. This interaction can lead to the modulation of HIGD1C's behavior, potentially influencing its role in mitochondrial function and cellular responses to hypoxia. Researchers are dedicated to unraveling the molecular mechanisms and functions of HIGD1C within the context of cellular hypoxia responses, aiming to gain insights into the intricate processes that allow cells to adapt and survive in oxygen-deprived conditions. The development of HIGD1C inhibitors represents an ongoing and dynamic area of research within the fields of molecular biology and pharmacology, contributing significantly to our understanding of cellular responses to hypoxia and their implications for various physiological and pathological states.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

An inhibitor of histone deacetylase that can alter chromatin structure and gene expression, potentially affecting HIGD1C expression.

N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine-d3

808118-40-3 unlabeledsc-488006
10 mg
$12000.00
(0)

A prolyl hydroxylase inhibitor that stabilizes HIF, potentially impacting hypoxia-responsive genes including HIGD1C.

Histone Lysine Methyltransferase Inhibitor Inhibitor

935693-62-2 (free base)sc-202651
5 mg
$151.00
4
(1)

A histone methyltransferase inhibitor that can alter the epigenetic state and expression of certain genes.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$231.00
$863.00
1
(0)

Inhibits BET bromodomain proteins, affecting transcriptional regulation of genes potentially including HIGD1C.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$53.00
$89.00
7
(1)

Alters various cellular pathways including proteasome inhibition, potentially affecting gene expression.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

A short-chain fatty acid that acts as an HDAC inhibitor, potentially influencing gene expression.

C646

328968-36-1sc-364452
sc-364452A
10 mg
50 mg
$265.00
$944.00
5
(1)

A selective p300/CBP histone acetyltransferase inhibitor, could affect transcription and thus HIGD1C expression.

Sirtinol

410536-97-9sc-205976
sc-205976A
1 mg
5 mg
$38.00
$113.00
14
(1)

An inhibitor of sirtuin deacetylases, may disrupt protein acetylation and gene expression.

I-CBP112

1640282-31-0sc-507494
25 mg
$400.00
(0)

A selective CBP/p300 bromodomain inhibitor, could alter chromatin structure and gene expression.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$218.00
$322.00
$426.00
7
(1)

A DNA methyltransferase inhibitor, could change DNA methylation status and gene expression, including HIGD1C.