Date published: 2026-5-30

1-800-457-3801

SCBT Portrait Logo
Seach Input

HIGD1A Inhibitors

HIGD1A inhibitors are a class of chemical compounds specifically designed to target and modulate the activity of the HIGD1A protein. HIGD1A, or Hypoxia-Inducible Gene Domain 1A, is a relatively recently discovered protein that plays a critical role in cellular responses to low oxygen levels, a condition known as hypoxia. This protein is primarily found in the mitochondria, the energy-producing organelles of cells, and it is involved in regulating mitochondrial function and adaptation to oxygen deprivation. HIGD1A inhibitors are designed to interfere with the function of this protein, either by blocking its activity or reducing its expression.

HIGD1A inhibitors has been driven by the growing interest in understanding the molecular mechanisms underlying cellular responses to hypoxia. These inhibitors are valuable research tools that enable scientists to investigate how HIGD1A functions within the mitochondria and how its activity impacts cellular physiology. By selectively inhibiting HIGD1A, researchers can gain insights into its downstream effects on mitochondrial function, oxygen sensing, and cellular adaptation to hypoxic conditions. Ultimately, a deeper understanding of HIGD1A and its inhibitors may provide novel insights into cellular biology and potentially uncover new avenues for addressing conditions associated with oxygen deprivation.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Coenzyme Q10

303-98-0sc-205262
sc-205262A
1 g
5 g
$71.00
$184.00
1
(1)

Coenzyme Q10 (ubiquinone) is involved in the mitochondrial electron transport chain which may interact with HIGD1A's role in cellular respiration.

Antimycin A

1397-94-0sc-202467
sc-202467A
sc-202467B
sc-202467C
5 mg
10 mg
1 g
3 g
$55.00
$63.00
$1675.00
$4692.00
51
(1)

By inhibiting complex III in the mitochondrial electron transport chain, Antimycin A disrupts the process in which HIGD1A is thought to be involved.

Rotenone

83-79-4sc-203242
sc-203242A
1 g
5 g
$89.00
$259.00
41
(2)

As an inhibitor of mitochondrial complex I, Rotenone can affect mitochondrial function, thereby influencing HIGD1A's role in hypoxia.

Sodium azide

26628-22-8sc-208393
sc-208393B
sc-208393C
sc-208393D
sc-208393A
25 g
250 g
1 kg
2.5 kg
100 g
$43.00
$155.00
$393.00
$862.00
$90.00
8
(2)

Sodium azide inhibits cytochrome c oxidase in the mitochondrial electron transport chain, thus it can affect HIGD1A's role.

Oligomycin A

579-13-5sc-201551
sc-201551A
sc-201551B
sc-201551C
sc-201551D
5 mg
25 mg
100 mg
500 mg
1 g
$179.00
$612.00
$1203.00
$5202.00
$9364.00
26
(1)

Oligomycin directly inhibits ATP synthase, impacting mitochondrial ATP production where HIGD1A may play a part.

FCCP

370-86-5sc-203578
sc-203578A
10 mg
50 mg
$94.00
$355.00
46
(1)

FCCP uncouples oxidative phosphorylation, which may indirectly influence HIGD1A's function.

2,4-Dinitrophenol, wetted

51-28-5sc-238345
250 mg
$59.00
2
(1)

As a chemical uncoupler of oxidative phosphorylation, it can interfere with the energy metabolism pathways involving HIGD1A.

Zinc

7440-66-6sc-213177
100 g
$48.00
(0)

Zinc has been shown to modulate mitochondrial function and could influence HIGD1A's activity indirectly.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$46.00
$122.00
$189.00
3
(1)

Copper can disrupt mitochondrial function and thus may have an indirect effect on HIGD1A activity.

Metformin

657-24-9sc-507370
10 mg
$79.00
2
(0)

Although primarily used for glucose metabolism, Metformin can influence mitochondrial respiration, which may indirectly affect HIGD1A.