HGK Inhibitors
Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate (HGK) is a critical component of cellular signaling pathways, playing a pivotal role in mediating various biological processes including cell growth, differentiation, survival, and apoptosis. As an adaptor protein, HGK is integral to the intricate network of signal transduction, facilitating the transmission of external signals to the internal machinery of the cell. This role involves the modulation of receptor tyrosine kinases, GTPases, and other signaling molecules, placing HGK at a crucial juncture where it can influence multiple signaling cascades. Its ability to act as a nexus for various pathways allows it to regulate a broad spectrum of cellular responses to environmental cues, thereby maintaining cellular homeostasis and responding to stress signals. Given its extensive involvement in critical cellular functions, HGK's activity is finely tuned and regulated within the cell, highlighting its significance in health and disease.
The inhibition of HGK, whether direct or indirect, encompasses a range of mechanisms that target the signaling pathways and processes it influences. Indirect inhibitors may act by modulating upstream activators or downstream effectors within the pathways where HGK operates. This approach can alter the signaling landscape, impacting HGK's ability to fulfill its regulatory functions. For example, targeting kinases or phosphatases that interact with HGK can modify its phosphorylation status, thereby affecting its activity and interaction with other signaling molecules. Similarly, molecules that influence the localization or stability of HGK can indirectly suppress its function by altering its availability or turnover. These inhibitory strategies do not target HGK directly but affect its operational context within the cell, leveraging the interconnected nature of signaling networks to modulate HGK's role. By understanding the complex web of interactions in which HGK participates, researchers can identify potential targets for indirect inhibition, offering insights into how cellular signaling can be modulated to influence the functions regulated by HGK.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
A tyrosine kinase inhibitor that targets RAF kinases, part of the MAPK/ERK pathway. By inhibiting this pathway, Sorafenib could reduce the activation of downstream signaling involved in cell growth and survival, indirectly affecting HGK's role in these processes. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Targets Src family kinases and c-Kit, which are involved in multiple signaling pathways, including those regulating cell growth and differentiation. Its inhibition of Src family kinases could indirectly suppress HGK by altering signaling networks where HGK plays a regulatory role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that can modulate the JNK signaling pathway, involved in cell stress responses and apoptosis. By inhibiting JNK activity, SP600125 could influence cellular processes where HGK is a regulatory component, potentially altering its function and expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that blocks the PI3K/AKT signaling pathway, crucial for cell survival and growth. LY294002's action could indirectly affect HGK by altering the cellular context and regulatory mechanisms where HGK operates, impacting its functional contributions to these pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
MEK inhibitor that blocks the MAPK/ERK pathway, a key signaling route for cell proliferation and differentiation. By inhibiting MEK, U0126 could indirectly modulate the activity and role of HGK within this pathway, affecting its regulatory impact on cell behavior. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that could indirectly affect HGK by modulating the p38 MAPK signaling pathway, involved in inflammatory responses and stress signaling. SB203580's inhibition of p38 MAPK could alter the regulatory landscape in which HGK functions. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that selectively blocks the activation of MAPK/ERK pathway. This action could indirectly influence HGK's involvement in signaling cascades related to cell proliferation and survival, potentially modifying its regulatory role. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor known to broadly affect the PI3K/AKT pathway, crucial for many cell functions including growth and survival. Wortmannin's inhibition of PI3K could indirectly impact HGK's regulatory roles in related signaling networks. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A Src family kinase inhibitor that can modify signaling pathways involving cell adhesion, growth, and differentiation. PP2's inhibition of Src kinases could indirectly affect HGK's regulatory functions in these pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor affecting the PI3K/AKT/mTOR pathway, important for cell growth and proliferation. Rapamycin's action could indirectly influence HGK's role by modifying the cellular environment and regulatory networks HGK is involved in. | ||||||