HEI10 Inhibitors
The class of HEI10 inhibitors comprises a diverse range of compounds that modulate the expression and function of HEI10, a protein involved in recombination and DNA repair processes. Camptothecin, a topoisomerase I inhibitor, directly affects HEI10 by stabilizing the topoisomerase I-DNA complex, leading to DNA breaks during replication. This disruption in DNA repair pathways influences HEI10 by altering the substrate availability for its action on recombination and repair processes. Proteasome inhibitors like MG-132 indirectly affect HEI10 by disrupting proteasome function, altering the degradation of ubiquitinated proteins. This modulation impacts HEI10 expression and function by regulating its protein turnover, thereby influencing cellular processes related to recombination and repair mechanisms. Olaparib, a PARP inhibitor, indirectly influences HEI10 by disrupting PARP-mediated DNA repair pathways, altering the availability of DNA substrates for its recombination function.
Bleomycin induces DNA breaks, indirectly modulating HEI10 by generating free radicals that cause DNA damage and alter the substrate availability for its action on recombination processes. Etoposide, a topoisomerase II inhibitor, directly affects HEI10 by stabilizing the topoisomerase II-DNA complex, leading to DNA breaks during replication. Cisplatin modulates HEI10 indirectly through DNA damage response, activating signaling pathways that affect HEI10 expression and function. Compounds like ATR Inhibitor and Caffeine indirectly impact HEI10 by disrupting ATR and ATM kinase-mediated DNA damage responses, respectively. These alterations in downstream pathways influence HEI10 by altering the availability of substrates for its recombination function. Additionally, 5-Fluorouracil modulates HEI10 indirectly through DNA synthesis inhibition, disrupting DNA replication and affecting the availability of substrates for its recombination function. This class of HEI10 inhibitors provides valuable insights into the intricate mechanisms governing HEI10 expression and function, shedding light on potential avenues for further research in recombination and DNA repair processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Topoisomerase I inhibitor affecting HEI10. Camptothecin binds to and stabilizes the topoisomerase I-DNA complex, leading to DNA breaks during replication. This disruption in DNA repair pathways influences HEI10 by altering the substrate availability for its action on recombination and repair processes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor indirectly affecting HEI10. MG-132 disrupts proteasome function, altering the degradation of ubiquitinated proteins. This modulation impacts HEI10 expression and function by regulating its protein turnover, thereby influencing cellular processes related to recombination and repair mechanisms. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor influencing HEI10 indirectly. Olaparib disrupts PARP-mediated DNA repair pathways, impacting HEI10 by altering the availability of DNA substrates for its recombination function. This modulation can influence HEI10 expression and function in the context of DNA damage response and repair mechanisms. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Induces DNA breaks, indirectly modulating HEI10. Bleomycin generates free radicals that cause DNA damage, impacting HEI10 by altering the substrate availability for its action on recombination processes. This modulation can influence HEI10 expression and function in the context of cellular responses to DNA damage. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Topoisomerase II inhibitor affecting HEI10. Etoposide stabilizes the topoisomerase II-DNA complex, leading to DNA breaks during replication. This disruption in DNA repair pathways influences HEI10 by altering the substrate availability for its action on recombination and repair processes. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Modulates HEI10 indirectly through DNA damage response. Cisplatin induces DNA damage, activating signaling pathways that affect HEI10 expression and function. The modulation of this pathway can influence HEI10 in the context of cellular responses to DNA damage and recombination processes. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $106.00 | 8 | |
Affects HEI10 indirectly through ATR kinase inhibition. ATR Inhibitor disrupts the ATR-mediated DNA damage response, impacting HEI10 by altering the availability of substrates for its recombination function. This modulation can influence HEI10 expression and function in the context of cellular responses to DNA damage and repair mechanisms. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
ATM kinase inhibitor influencing HEI10 indirectly. Caffeine disrupts the ATM-mediated DNA damage response, altering downstream pathways that influence HEI10 expression and function. This modulation can influence HEI10 in the context of cellular responses to DNA damage and recombination processes. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Modulates HEI10 indirectly through DNA synthesis inhibition. 5-Fluorouracil disrupts DNA replication, impacting HEI10 by altering the availability of substrates for its recombination function. This modulation can influence HEI10 expression and function in the context of cellular responses to DNA damage and repair mechanisms. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Microtubule inhibitor indirectly affecting HEI10. Nocodazole disrupts microtubule dynamics, altering cellular processes that influence HEI10 expression and function. This modulation can impact HEI10 in the context of recombination and repair mechanisms by affecting the cellular environment necessary for its proper function. | ||||||