HEI10 Activators
HEI10 activators are a series of chemical compounds that indirectly enhance the activity of HEI10 by influencing various cellular signaling pathways and biological processes. Resveratrol elevates the activity of sirtuin pathways, notably SIRT1, which is pivotal in deacetylation mechanisms integral to cell cycle and DNA repair functions, hence facilitating HEI10's role in homologous recombination and meiotic crossovers. AICAR, an AMPK activator, boosts the energy-sensing AMPK pathway, indirectly promoting HEI10's involvement in cellular energy regulation and the DNA damage response. Pioglitazone activates PPAR-gamma, a nuclear receptor involved in lipid metabolism, potentially enhancing the expression of genes that upregulate HEI10's ubiquitin ligase activity, crucial for maintaining genomic integrity. Urolithin A induces autophagy, leading to the removal of damaged mitochondria, supporting cellular repair mechanisms that may indirectly augment HEI10's genomic stability functions.
The action of Rapamycin on mTOR inhibition can also indirectly foster HEI10's role in cell cycle checkpoint control, linking DNA damage response pathways with mTOR activity. Metformin, by activating AMPK, influences metabolic pathways, indirectly supporting HEI10 in DNA repair and maintenance of genomic stability by modifying the cellular response to metabolic stress. The antioxidant properties of Oleuropein may enhance DNA repair mechanisms, indirectly aiding HEI10's homologous recombination function. Sulforaphane activates Nrf2 and can enhance HEI10's DNA repair role by upregulating genes involved in cellular redox homeostasis. Quercetin's PI3K inhibition may also amplify HEI10's function in DNA damage response by diminishing competitive survival signaling. Spermidine promotes autophagy, indirectly supporting HEI10's genome maintenance role by enhancing cellular component recycling. Nicotinamide mononucleotide boosts NAD+ levels, indirectly supporting HEI10 activity by promoting DNA repair pathways. Lastly, Curcumin activates cellular stress response pathways, potentially aiding HEI10's role in DNA damage response and repair processes.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol enhances the sirtuin pathways, particularly SIRT1, which is involved in the deacetylation of proteins related to cell cycle control and DNA repair. This action can upregulate HEI10's role in homologous recombination and meiotic crossover. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which is a sensor of cellular energy status. Activation of AMPK can indirectly lead to the enhancement of HEI10's function by influencing the cell's energy balance and DNA damage response mechanisms. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone activates PPAR-gamma, a nuclear receptor that plays a role in lipid metabolism and adipogenesis. Its activation may promote the expression of downstream targets that can enhance the ubiquitin ligase activity of HEI10. | ||||||
Urolithin A | 1143-70-0 | sc-475514 sc-475514A sc-475514B sc-475514C | 25 mg 100 mg 1 g 5 g | $200.00 $450.00 $700.00 $1200.00 | 10 | |
Urolithin A, a metabolite of ellagic acid, induces mitophagy and autophagy. By promoting the clearance of damaged mitochondria, it can enhance cellular repair processes, which may indirectly support the role of HEI10 in maintaining genomic stability. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism. By inhibiting mTOR, Rapamycin may indirectly enhance the activity of HEI10 in the cell cycle checkpoint control, as mTOR activity is linked to DNA damage response pathways. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin activates AMPK and can influence cellular metabolism and growth. This activation indirectly supports HEI10's function in DNA repair and maintenance of genomic stability by modulating the cell's energy status and response to metabolic stress. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $352.00 $520.00 $775.00 $6640.00 | 2 | |
Oleuropein has been shown to have antioxidant properties and can enhance DNA repair mechanisms. This enhancement could support the role of HEI10 in homologous recombination by improving the overall cellular environment for DNA repair processes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, a transcription factor that regulates antioxidant response elements. This activation can indirectly enhance HEI10's role in DNA repair by upregulating the expression of genes involved in maintaining cellular redox balance. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to inhibit PI3K, a kinase involved in cell survival signaling. By inhibiting PI3K, Quercetin could indirectly enhance HEI10's function in DNA damage response pathways by reducing competitive survival signaling that may suppress DNA repair. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is a polyamine that promotes autophagy and can aid in cellular rejuvenation. By enhancing autophagy, Spermidine may indirectly support HEI10's role in genome maintenance by facilitating the recycling of cellular components and reducing genomic stress. | ||||||